| 王纪源,葛圣林,冯俊波.左西孟旦对犬体外循环术后肺保护的实验研究[J].安徽医药,2015,19(9):1657-1660. |
| 左西孟旦对犬体外循环术后肺保护的实验研究 |
| The study of levosimendan on experimental canine lung protection during cardiopulmonary bypass surgery |
| 投稿时间：2015-03-19 |
| DOI： |
| 中文关键词: 左西孟旦 体外循环 肺保护 |
| 英文关键词: levosimendan cardiopulmonary bypass lung protection |
| 基金项目:安徽省高等学校省级自然科学研究项目(No KJ2013Z108) |
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| 中文摘要: |
| 目的 探索左西孟旦(LS)对实验用杂种犬体外循环(CPB)术后急性肺损伤(ALI)是否具有保护作用。 方法 实验用杂种犬32只,随机分为4组,对照组(C组),氧和冷血肺动脉灌注组(P组),LS静脉注射组(LSIV)；含LS的氧和冷血肺动脉灌注组(LSP组),LS的剂量均为65 g·kg-1；检测各组肺组织中丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性,光镜及电镜观察肺组织的病理形态学变化。 结果 肺组织中MDA含量及SOD活性,与C组相比,LSP组、P组及LSIV组MDA含量明显降低,且SOD活性明显升高(P<0.01),与LSP组相比,LSIV组及P组MDA含量明显升高,且SOD活性明显降低(P<0.01),P组和LSIV组无统计学意义(P>0.05)。 结论 通过犬动物实验模型,单纯肺动脉灌注、肺动脉灌注及静脉注射LS,MDA含量明显减少,SOD活性增高,对肺组织具有保护作用 |
| 英文摘要: |
| Objective LS explore experimental surgery with CPB ALI whether dogs have a protective effect. Methods Experiment with 32 dogs were randomly divided into four groups:control group(group C);oxygen and cold-blooded pulmonary perfusion group(P group);LS intravenous group(LSIV);LS containing oxygen and cold-blooded pulmonary perfusion group(LSP group),LS doses are 65 g·kg-1;detect the pathological changes of the lung tissue malondialdehyde(MDA),superoxide dismutase(SOD)activity,light microscopy and electron microscopy of lung tissue. Results Lung tissue MDA content and SOD activity,compared with group C,LSP group,P group and MDA LSIV significantly decreased,and SOD activity was significantly increased(P<0.01),compared with the LSP group,LSIV group and Pgroup were significantly increased MDA and SOD activity was significantly lower(P<0.01),P group and LSIV groups was not statistically significant(P>0.05). Conclusion By canine animal models,simple pulmonary perfusion,pulmonary perfusion and intravenousLS,decreased MDA content,SOD activity increased,has a protective effect on lung tissue |
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