| 朱 涛,戴小华,杨 帆 .复方丹参滴丸治疗糖尿病肾病疗效及安全性的Meta分析[J].安徽医药,2015,19(9):1791-1794. |
| 复方丹参滴丸治疗糖尿病肾病疗效及安全性的Meta分析 |
| Compound danshen dropping pills to treat diabetic nephropathy Meta analysis |
| 投稿时间：2014-11-20 |
| DOI： |
| 中文关键词: 复方丹参滴丸 糖尿病肾病 Meta分析 |
| 英文关键词: compound danshen dropping pills diabetic nephropathy Meta analysis |
| 基金项目:安徽省2013年高校省级自然基金科研项目(No KJ2013Z166) |
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| 中文摘要: |
| 目的 评价复方丹参滴丸治疗糖尿病肾病的疗效及安全性。方法 计算机检索2006年9月至2014年9月,全面检索万方数据库、维普数据库、中国学术期刊全文数据库、中国生物医学文献数据库、Pubmed数据库,收集复方丹参滴丸治疗糖尿病肾病的试验,根据纳入和排除标准共纳入14项研究,1 051例患者,选用空腹血糖、餐后2 h血糖、血肌酐、尿素氮、尿β2微球蛋白、尿微量白蛋白排泄率作为效应指标,使用RevMan5.0软件进行meta分析。结果(1)空腹血糖[WMD=-0.15,95%的CI为(-0.38,0.09),P=0.22],差异无显著性；餐后两小时血糖[WMD=-0.49,95%的CI为(-0.90,-0.08),P=0.02],差异具有统计学意义,治疗组均优于对照组(2)血肌酐[WMD=-1.74,95%的CI为(-5.40,1.92),P=0.35],差异无显著性；尿素氮[WMD=0.07,95%的CI为(-0.18,0.32),P=0.59],差异无显著性。(3)尿微量白蛋白排泄率[WMD=-11.95,95%的CI为(-16.27,-7.64),P<0.00001],差异具有统计学意义,治疗组均优于对照组。结论 证据表明,复方丹参滴丸治疗糖尿病肾病疗效性、安全性较高。 |
| 英文摘要: |
| Objective To evaluate the effect of compound danshen dropping pills to treat diabetic nephropathy,and safety.Methods computer retrieval from September 2006 to September 2014,comprehensive retrieve database,weipu database of ten thousand,China academic journal full-text database and Chinese biomedical literature database,Pubmed database,collection of compound danshen dropping pills in the treatment of diabetic nephropathy,according to include and exclude standards into 14 study,1 051 patients,choose Fasting plasma glucose,postprandial 2 hours blood glucose,serum creatinine,blood urea nitrogen,urine trace albumin excretion rate as an index of effect,use RevMan5.0 meta analysis software.Results (1)fasting glucose(WMD = -0.15,5% CI (-0.38,0.09),P = 0.22),there was no significant difference;Two hours after meal the blood sugar (WMD = -0.49,5% CI (-0.90,-0. 08),P = 0.02),statistically significant difference,the treatment group were superior to control group. (2) serum creatinine(WMD =-1.74,95% CI (-5.40,1.92),P = 0.35),there was no significant difference; blood urea nitrogen (WMD =0.07,5% CI(-0.18,0.32),P = 0.59),there was no significant difference. (3) Urine trace albumin excretion rate (WMD = -11.95,5% CI (-16.27,-7.64),P < 0.00001),statistically significant difference,the treatment group were superior to the control group.Conclusion evidence that the compound danshen dropping pills in treatment of diabetic nephropathy curative effect,high safety. |
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