| 刘晓敏,陈银河,申才良.Matrilin-1基因rs1149048单核苷酸多态性与青少年特发性脊柱侧凸易感性的Meta分析[J].安徽医药,2015,19(10):1933-1936. |
| Matrilin-1基因rs1149048单核苷酸多态性与青少年特发性脊柱侧凸易感性的Meta分析 |
| A Meta-analysis on the association between rs1149048 polymorphism of Matrilin 1 gene and susceptibility to adolescent idiopathic scoliosis |
| 投稿时间：2015-03-10 |
| DOI： |
| 中文关键词: 脊柱侧凸 青少年 Matrilin-1基因 单核苷酸多态性 Meta分析 |
| 英文关键词: scoliosis adolescent Matrilin-1 single nucleotide polymorphism Meta-analysis |
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| 中文摘要: |
| 目的 综合分析Matrilin-1基因rs1149048单核苷酸多态性(SNP)与青少年特发性脊柱侧凸(AIS)易感性的关系。 方法 计算机检查Medline、Cochrane图书馆、Ovid、Wiley Online图书馆、EBSCO、 Elsevier Science Direct、Springer、CBM、CNKI、万方、维普等数据库,查询关于Matrilin-1 rs1149048 SNP与AIS易感性的病例对照文献,利用Revman 5.3和Stata12.0软件分析相关数据。 结果 最终共有4篇文献纳入。结果显示GG基因型[OR=1.21,5%CI(0.93,1.56),P=0.15]、AA基因型[OR=0.92,95%CI(0.75,1.13),P=0.44]与AIS易感性无关联性,G等位基因[OR=1.12,5%CI(1.01,1.24),P=0.03]、A等位基因[OR=0.89,5%CI(0.80,0.99),P=0.03]与AIS易感性有关联性。仅GG基因型有明显异质性(P=0.10,I2=52%),剔除来自日本的研究后,异质性降低(P=0.19,I2=41%),结果发生明显变化[OR=1.39,5%CI(1.10,1.75),P=0.005],提示该研究为异质性来源之一。纳入文献仅4篇,发表偏倚未评估。 结论 Matrilin-1 rs1149048 G和A等位基因与AIS的易感性有关联性,G等位基因携带者对AIS的易感性增高。 |
| 英文摘要: |
| Objective To investigate the association between rs1149048 polymorphism of Matrilin-1 gene and the susceptibility to AIS by a meta-analysis. Methods Case-control studies were searched from Medline,Cochrane Library,Ovid,Wiley Online Library,EBSCO,Elsevier Science Direct,Springer,CBM,CNKI,Wan Fang and Wei Pu databases for the association between Matrilin-1 rs1149048 polymorphisms and the susceptibility to AIS.Meta-analysis was performed by Revman 5.3 and Stata 12.0 software.Pooled odds ratio(OR)with 95% confidence interval(CI)were derived from random-effects or fixed-effects models to assess the strength of the association. Results Four case-control studies were included in the final meta-analysis.No statistically significant differences between AIS and controls group were observed between the susceptibility to AIS and Matrilin-1 rs1149048 genotype GG [OR=1.21,5%CI(0.93,1.56),P=0.15] and AA [OR=0.92,5%CI(0.75,1.13),P=0.44];however,significant differences in allele G [OR=1.12,5%CI(1.01,1.24),P=0.03] and allele A [OR=0.89,5%CI(0.80,0.99),P=0.03] were observed between AIS and control groups.There was obvious heterogeneity among the studies in Genotype GG(P=0.10,I2=52%),sensitivity analysis performed by omitting one study at a time.When a Japanese study was omitted,the heterogeneity decreased(P=0.19,I2=41%),and the pooled results were statistically significant [OR=1.39,5%CI(1.10,1.75),P=0.005],indicating that it might be a source of heterogeneity.Because there were only four studies included,the assessment of publication bias was not performed. Conclusions This meta-analysis reveals that alleles Gand Aof Matrilin-1 rs1149048 are associated with the susceptibility to AIS.G-allele carriers have higher susceptibility. |
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