| 徐燕,刘存义,宋雷.术前阿托伐他汀强化治疗对经皮冠状动脉介入术后外周血T细胞亚群的影响[J].安徽医药,2017,21(2):360-363. |
| 术前阿托伐他汀强化治疗对经皮冠状动脉介入术后外周血T细胞亚群的影响 |
| Effects of intensive atorvastatin therapy on peripheral blood of Tlymphocyte subsets in patients with unstable angina after percutaneous coronary intervention |
| 投稿时间：2016-06-01 |
| DOI： |
| 中文关键词: 心绞痛,不稳定 阿托伐他汀 T淋巴细胞 经皮冠状动脉介入术 |
| 英文关键词: Angina pectoris,unstable Atorvastatin T lymphocyte Percutaneous coronary intervention |
| 基金项目: |
|
| 摘要点击次数: 2225 |
| 全文下载次数: 618 |
| 中文摘要: |
| 目的 探讨术前阿托伐他汀强化治疗对不稳定心绞痛(UA)病人经皮冠状动脉介入术(PCI)术后外周血T细胞亚群的影响。方法 选取行 PCI 术的 UA 病人210例,根据治疗方式的不同分为高负荷组、常规负荷组、对照组,每组70例。高负荷组病人术前2 d口服阿托伐他汀钙80 mg,术后继续维持40 mg·d-1,每天1次；常规负荷组病人术前2 d口服阿托伐他汀钙40 mg,术后继续维持20 mg·d-1,每天1次；对照组病人术前2 d口服阿托伐他汀钙20 mg ,术后继续维持20 mg·d-1。术前1 d,术后1周、1个月 、6个月再分别采取静脉血2 mL,分析外周血T细胞亚群CD4＋,CD8＋细胞及CD4＋CD25＋调节性 T 细胞(CD4＋CD25＋Treg)比例。结果 CD4＋细胞术后1周、1个月及6个月的细胞比例相较于术前均明显降低,且时间越长,下降越明显(P<0.05)；CD8＋术后1周、1个月及6个月的细胞比例相较于术前明显升高,且时间越长,升高越明显(P<0.05)。且在1个月及6个月时,常规负荷组及对照组与高负荷组比较,差异有统计学意义(P<0.05)。CD4＋CD25＋Treg/CD4＋T 细胞术后1周、1个月及6个月相较于术前均明显升高,且时间越长,升高越明显(P<0.05),且在6个月时间节点的比较中,与常规负荷组及对照组比较,高负荷组变化更为明显,差异有统计学意义(P<0.05)。结论 UA 病人术后可以通过服用他汀类药物以调节 T细胞亚群的比例,降低免疫炎性反应,改善动脉粥样硬化发生发展,且安全范围内的高负荷量阿托伐他汀的临床疗效更显著。 |
| 英文摘要: |
| Objective To observe the effects of intensive atorvastatin therapy on peripheral blood of T lymphocyte subsets in patients with unstable angina after percutaneous coronary intervention(PCI).
Method Totally 210 patients with unstable angina after PCI were randomly selected into high load group,normal load group and control group,70 cases in each.The high load group were given oral atorvastatin calcium 80 mg,2 days before PCI,postoperatively 40 mg,1 time per day.The normal load group were given atorvastatin calcium 40 mg,2 days before PCI,postoperatively 20 mg,1 time per day.The control group were given atorvastatin calcium 20 mg before and after PCI 20 mg 1 times per day.2 mL venous blood were taken in 1 day before surgery and1 week,1 month,6 months after surgery respectively.The ratio of CD4+,CD8+ cells and CD4+CD25+Treg cells was analyzed.〖HT5"H〗〖WTHZ〗〖STHZ〗
Result The proportion of CD4+ cells in 1 week,1 months and 6 months after surgery was significantly lower than that before surgery,and it decreased significantly over time (P<0.05).The proportion of CD8+ cells in 1 week,1 months and 6 months after surgery was significantly higher than that before surgery,and increased significantly over time(〖WTBX〗P〖WTBZ〗<0.05).Compared with normal load group and control group in 1 months and 6 months,the difference in high load group was statistically significant (〖WTBX〗P〖WTBZ〗<0.05).The proportion of CD4+ CD25+Treg/CD4+ T cell in patients after 1 week,1 month and 6 month were significantly increased than that before surgery,and the change increased significantly over time (〖WTBX〗P〖WTBZ〗<0.05).Compared with the conventional load group and the control group,the change in high load group was more obvious (〖WTBX〗P〖WTBZ〗<0.05).〖HT5"H〗〖WTHZ〗〖STHZ〗
Conclusion It′s useful to regulate the proportion of T cell subsets,reduce the immune inflammatory reaction and reverse atherosclerosis by taking atorvastatin.The clinical curative effect of high dose atorvastatin is more significant. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
