| 王琴,周俊平,桂东,等.奥沙利铂联合替吉奥与顺铂联合5-氟尿嘧啶方案在食管胃结合部腺癌辅助化疗中的疗效评价[J].安徽医药,2017,21(2):364-367. |
| 奥沙利铂联合替吉奥与顺铂联合5-氟尿嘧啶方案在食管胃结合部腺癌辅助化疗中的疗效评价 |
| Comparison of efficacy and safety between SOX regimen and PF regimen as adjuvant chemotherapy for adenocarcinoma of esophagogastric junction |
| 投稿时间：2016-06-08 |
| DOI： |
| 中文关键词: 食管胃结合部腺癌 辅助化疗 奥沙利铂联合替吉奥方案 顺铂联合5-氟尿嘧啶方案 |
| 英文关键词: Adenocarcinoma of esophagogastric junction Adjuvant chemotherapy SOX regimen PF regimen |
| 基金项目: |
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| 中文摘要: |
| 目的 比较奥沙利铂联合替吉奥(SOX)与顺铂联合5-氟尿嘧啶(PF)方案治疗食管胃结合部腺癌根治术后病人的疗效、安全性及生活质量。方法 食管胃结合部腺癌根治术后病理分期为Ⅲ期的病人入选试验,按随机数字表法分为两组,分别接受SOX方案或PF方案化疗,共入组82例,观察组38例,对照组44例,主要评价指标为病人的无病生存期(DFS)、总生存期(OS)、不良反应及生活质量。结果 SOX方案组与PF方案组的中位DFS分别为29.3个月和18.4个月(P<0.05),中位OS分别为35.9个月和24.8个月(P<0.05)。两组毒副反应主要是血液系统异常,以Ⅰ～Ⅱ度为主,差异无统计学意义。SOX方案组外周神经系统毒性发生率较PF方案组高(P<0.05),但均在可耐受范围内；且生活质量的改善明显高于PF组,差异有统计学意义(P<0.05)。结论 SOX作为食管胃结合部腺癌根治术后辅助化疗方案,同PF方案相比,病人的中位DFS及OS均延长,毒副反应均可耐受,给药方便,生活质量改善明显,具有明显的优势。 |
| 英文摘要: |
| Objective To evaluate the efficacy,toxicity and quality of life of S-1 plus oxaliplatin(SOX)versus 5-FU plus cisplatin(PF)as adjuvant chemotherapy for adenocarcinoma of esophagogastric junction(AEG). Methods Patients with AEG who had accepted radical operation and the pathological stage which was Ⅲ stage were eligible for inclusion.Patients were randomly assigned to receive SOX regimen or PF regimen.Eighty-two patients with AEG who had accepted radical operations were enrolled.38 patients were in the experimental group and 44 patients were in the control group.The major evaluation parameters were disease-free survivaI(DFS),overall survival(OS)and toxicity as well as quality of life. Results For SOX and PF regimens,the median DFS were 29.3 months and 18.4 months,respectively(P<0.05),and the median OS were 35.9 months and 24.8 months,respectively(P<0.05).The major adverse reaction of these two groups was the hematologic toxicity,mainly gradeⅠ～Ⅱwith no significant statistical difference.The incidence of peripheral neurotoxicity in SOX regimen was higher than that in PF regimen(P<0.05).However,the toxicities were tolerable.The condition of improvement of the quality of life was significantly better than PF regimen(P<0.05),with statistical significance. ConclusionCompared with PF regimen,the SOX regimen as the postoperative adjuvant chemotherapy of AEG can prolong the median DFS and OS,toxicity can be tolerated.The drug administration was convenient,and the quality of life was improved significantly.The results of this retrospective analysis indicate that SOX regimen has obvious advantages over PF regimen. |
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