体质量指数对维吾尔族中、重度慢性阻塞性肺疾病急性加重病人肺功能及血气、凝血、血红蛋白的影响

张艳新; 李风森; 李争; 高振; 徐丹; 荆晶

文章摘要

张艳新,李风森,李争,等.体质量指数对维吾尔族中、重度慢性阻塞性肺疾病急性加重病人肺功能及血气、凝血、血红蛋白的影响[J].安徽医药,2017,21(5):831-833.

体质量指数对维吾尔族中、重度慢性阻塞性肺疾病急性加重病人肺功能及血气、凝血、血红蛋白的影响

The influence of BMI on lung function,blood gas analysis,blood coagulation and hemoglobin in Uygur AECOPD patients in medium and severe stage

投稿时间：2016-08-08

DOI：

中文关键词: 慢性阻塞性肺疾病急性加重体质量指数维吾尔族肺功能血气分析

英文关键词:

基金项目:新疆维吾尔自治区科技创新团队培养建设项目(2014751005)

作者	单位	E-mail
张艳新	新疆医科大学附属中医医院呼吸科,新疆乌鲁木齐 830000
李风森	新疆医科大学附属中医医院呼吸科,新疆乌鲁木齐 830000 新疆·国家中医临床研究基地,新疆乌鲁木齐 830000 新疆呼吸病研究实验室,新疆乌鲁木齐 830000	fengsen602@163.com
李争	新疆医科大学附属中医医院呼吸科,新疆乌鲁木齐 830000 新疆·国家中医临床研究基地,新疆乌鲁木齐 830000 新疆呼吸病研究实验室,新疆乌鲁木齐 830000
高振	新疆医科大学附属中医医院呼吸科,新疆乌鲁木齐 830000 新疆·国家中医临床研究基地,新疆乌鲁木齐 830000 新疆呼吸病研究实验室,新疆乌鲁木齐 830000
徐丹	新疆医科大学附属中医医院呼吸科,新疆乌鲁木齐 830000 新疆·国家中医临床研究基地,新疆乌鲁木齐 830000 新疆呼吸病研究实验室,新疆乌鲁木齐 830000
荆晶	新疆医科大学附属中医医院呼吸科,新疆乌鲁木齐 830000 新疆·国家中医临床研究基地,新疆乌鲁木齐 830000 新疆呼吸病研究实验室,新疆乌鲁木齐 830000

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中文摘要:

目的探讨不同体质量指数(BMI)对维吾尔族中、重度慢性阻塞性肺疾病急性加重(AECOPD)病人肺功能及血气、凝血、血红蛋白的影响。方法选取2013年1月—2014年12月入院诊断为AECOPD的中、重度维吾尔族病人128例,将病人按照BMI分成低、正常、高三组,分析三组之间肺功能、血气分析、凝血功能及血红蛋白结果之间的差异。结果低BMI组病人的支气管舒张试验后1秒用力呼气量(FEV₁)、用力肺活量(FVC)、 FEV₁/FVC均显著低于正常BMI组和高BMI组(P＜0.01)；血气分析结果比较,低BMI组的PaCO₂高于50 mmHg,且显著高于正常BMI组(P=0.022),低BMI组的pH值显著低于正常BMI组(P=0.012)；凝血功能中,低BMI组(P=0.049)和高BMI组(P=0.024)的凝血酶原时间(PT)值显著低于正常BMI组,高BMI组的凝血酶时间(TT)值显著低于低BMI组(P=0.000),而活化部分凝血酶原时间(APTT)值显著高于低BMI组(P=0.000),纤维蛋白原(FIB)值三组之间无显著差异性,但随着BMI增加FIB结果有增高趋势；血红蛋白结果显示低BMI组(P=0.002)及高BMI组(P=0.000)均显著高于正常BMI组。结论低BMI的维吾尔族中、重度慢性阻塞性肺疾病(COPD)病人肺功能更差,危险程度更高,更容易造成栓塞性疾病及呼吸衰竭。

英文摘要:

Objective To explore the influence of body mass index on lung function,blood gas analysis,blood clotting function and hemoglobin in Uygur AECOPD patients in medium and severe stage.Methods Collect 128 Uygur COPD patients in medium and severe stage in our Hospital from 2013 to 2014 years admitted to diagnosis of AECOPD,the patients were divided according to BMI into low,normal,and high group,analysis the differences of lung function,blood gas analysis,blood coagulation and hemoglobin among the three groups.Results Patients with low BMI group of FEV₁,FVC,FEV₁/FVC were significantly lower than the normal BMI group and high BMI groups (P<0.01);the comparison of blood gas analysis,PaCO₂ in low BMI group was higher than 50 mmHg,and significantly higher than normal BMI group (P=0.022),PH value in low BMI group was significantly lower than the normal BMI group (P=0.012);in comparison of coagulation,the low BMI group (P=0.049) and high BMI groups (P=0.024) of PT value significantly lower than the normal BMI group,TT value of the high BMI group was significantly lower than the low BMI group (P=0.000),and APTT values are significantly lower than the high BMI group (P=0.000),no significant differences between the FIB value of the three groups,but with increasing BMI FIB result has tended to increase;hemoglobin showed that low BMI group (P=0.002) and high BMI groups (P=0.000) were significantly higher than normal BMI group.Conclusions Low BMI index Uygur COPD patients in medium and severe stage has worse lung function,higher degree of risk,more likely to cause embolism and respiratory failure.

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