| 陶利,吴继雄.血小板-淋巴细胞计数比值与急性冠脉综合征冠脉病变严重程度的相关性研究[J].安徽医药,2017,21(7):1215-1219. |
| 血小板-淋巴细胞计数比值与急性冠脉综合征冠脉病变严重程度的相关性研究 |
| Association of platelet-to-lymphocyte ratio with the severity of coronary lesion in patients with acute coronary syndrome |
| 投稿时间：2016-10-12 |
| DOI： |
| 中文关键词: 急性冠脉综合征 血小板-淋巴细胞计数比值 冠脉病变程度 血小板 淋巴细胞 |
| 英文关键词: Acute coronary syndrome Platelet-to-lymphocyte ratio Severity of coronary lesion Platelet Lymphocyte |
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| 中文摘要: |
| 目的 探讨血小板-淋巴细胞计数比值(PLR)与急性冠脉综合征(ACS)冠脉病变严重程度的相关性及其对中-重度病变的预测价值。 方法 收集行冠脉造影的ACS病人118例,依据SYNTAX积分将ACS分为两组:轻度冠脉病变组72例(≤22分) 和中-重度冠脉病变组46例(＞22分),选择同期入院经冠脉造影排除冠心病者55例。入院时即刻抽取肘静脉血2 mL于EDTA-K2真空管中,混匀,立即送检检验科,血常规采用全自动血细胞分析仪测定,计算PLR。比较3组间临床基线资料、实验室资料,分析PLR与SYNTAX积分的相关性,PLR对中-重度冠脉病变组的独立预测价值。 结果 3组间年龄、性别、吸烟、白细胞计数、PLR、肌钙蛋白I、超敏C反应蛋白、肌酐差异有统计学意义。3组间PLR两两比较均差异有统计学意义[非冠心病组(95.79±28.23),轻度冠脉病变组(110.53±38.2),中-重度冠脉病变组(146.40±50.37),P<0.001]。将PLR分为<100、100~<150、150~<200、200~<250、250~<300 5个等级,单因素、多因素Logistic回归分析,显示其是ACS中-重度冠脉病变独立预测因素(OR 3.148,5%CI 1.886~5.254,P<0.001)。PLR与SYNTAX积分成正相关(r=0.401,P<0.001)。受试者工作特征曲线 (ROC曲线) 显示 PLR的曲线下面积0.714 (95%CI 0.624~0.804,P<0.001),最佳截断值为114.26,敏感性73.9%,特异性64.6%。 结论 PLR与ACS冠脉病变严重程度正相关,是预测中-重度病变的独立预测因素。 |
| 英文摘要: |
| Objective To investigate the association of platelet-to-lymphocyte ratio (PLR) with the severity of coronary lesion as assessed by the SYNTAX score in patients with acute coronary syndrome (ACS) who underwent coronary angiography (CA). Methods A total of 118 patients with ACS and 55 patients without coronary artery disease who underwent CA were included in the study.The patients with ACS were assigned into two groups,mild coronary lesion group with SYNTAX score ≤22 (n=72),and moderate-severe coronary lesion group with SYNTAX score ＞22 (n=46).In all patients,venous blood samples were drawn immediately on hospital admission.Platelet count and lymphocyte count were measured by full-automatic blood cell′s analyzer,then PLR was calculated.Baseline clinical data and laboratory datum were compared among three groups.Correlation of PLR with SYNTAX score and predictive value of PLR for moderate-severe coronary lesion group were examined. Results Age,gender,smoking,white blood cell count,PLR,troponin I,Hs-CRP and creatinine were significantly different among three groups (P<0.05).There were significant differences in PLR between every two of the three groups [(95.79±28.23) in group without coronary artery disease,(110.53±38.2) in mild coronary lesion group,(146.40±50.37) in moderate-severe coronary lesion group,P<0.001].In multivariate analysis,PLR that was classified into five levels,respectively <100,0-<150,0-<200,0-<250 and 250-<300,was an independent predictor of moderate-severe coronary lesion (OR 3.148,95%CI 1.886-5.254,P<0.001).There was a positive correlation between PLR and SYNTAX score (r=0.401,P<0.001).Receiver-operating characteristic curve demonstrated that the cut-off value of PLR to predict moderate-severe coronary lesion was 114.26,with 73.9% sensitivity and 64.6% specificity (area under the curve 0.714,5% CI 0.624-0.804,P<0.001). Conclusions PLR is positively correlated to the severity of coronary lesion and it is an independent predictor of moderate-severe coronary lesion in patients with ACS. |
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