| 石芳,吴晓安,董书春,等.番泻叶颗粒剂治疗癌痛病人阿片类药物相关性便秘的临床疗效观察[J].安徽医药,2017,21(7):1302-1305. |
| 番泻叶颗粒剂治疗癌痛病人阿片类药物相关性便秘的临床疗效观察 |
| Clinical research of senna granule for the treatment of opioid-induced constipation in cancer patients with pain |
| 投稿时间：2016-07-21 |
| DOI： |
| 中文关键词: 番泻叶颗粒剂 癌痛 阿片类药物相关性便秘 |
| 英文关键词: Senna granules Cancer pain Opioid-induced constipation |
| 基金项目: |
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| 摘要点击次数: 2230 |
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| 中文摘要: |
| 目的 观察番泻叶颗粒剂治疗癌痛病人阿片类药物相关性便秘(OIC)的疗效。 方法 选取患有OIC的癌痛病人120例,采用随机数字表法分为治疗组(番泻叶颗粒剂组)和对照组(乳果糖口服溶液组),分别采用番泻叶颗粒剂和乳果糖口服溶液治疗。根据肠功能指数(BFI)量表对病人便秘进行评分,比较两组病人治疗前、后的便秘评分和治疗疗效,并比较两组病人毒副反应的发生。 结果 治疗组60例病人治疗便秘的总有效率为98.3%,对照组60例病人治疗便秘的总有效率为76.67%。秩和检验比较两组病人的治疗疗效,Z值为-3.82,P＜0.05,差异有统计学意义。可认为番泻叶颗粒剂治疗癌痛病人OIC疗效高于乳果糖口服溶液。对两组病人治疗前、后便秘评分进行比较,治疗组治疗前、后的便秘评分分别为(68.78±13.18)分和(14.50±10.52)分,对结果进行t检验,差异有统计学意义(t=31.2,P<0.05)。对照组治疗前、后的便秘评分分别为(69.89±12.07)分和(26.62±20.23)分。两组治疗前便秘评分差异无统计学意义(t=0.482,P=0.63),两组治疗后便秘评分差异有统计学意义(t=-4.12,P<0.05),治疗组在降低便秘评分上优于对照组。两组病人腹痛(Z=-1.96,P＞0.05)、腹泻(Z=-1.97,P＞0.05)以及呕吐(Z=-0.58,P＞0.05)的发生比较,差异无统计学意义。 结论 番泻叶颗粒剂能有效治疗阿片类药物相关性便秘,且毒副反应轻微。 |
| 英文摘要: |
| Objective To evaluate the therapeutic efficacy of senna granule for the treatment of opioid-induced constipation (OIC) in cancer patients with pain. Methods Selected 120 cases of cancer pain patients with OIC in the oncology department of PLA 174 Hospital,which were randomly assigned into 2 groups,treatment group (the senna granule group) and control group (the lactulose group),respectively treated with senna granules and lactulose oral solution.The constipation scores were evaluated by BFI scale,compare the constipation scores between the two groups before and after treatment,at the same time compare the curative effect in the treatment of OIC and toxic and side effect between two groups. Results The total effective rate in 60 patients of treatment group was 98.30%.The total effective rate in 60 patients of control group was 76.67%.Rank-sum test comparison of the two groups of curative effect,the Zvalue is -3.82,P <0.05,the difference was statistically significant.Senna granule in the treatment of pain patients with OIC can be thought of more effective than that of lactulose.Compared the constipation score between the two groups,the mean constipation score in treatment group before and after treatment was (68.78±13.18) and (14.50±10.52) respectively.Statistical comparisons were made using t test,the difference was statistically significant (t=31.2,P<0.05).The mean constipation score in control group before and after the treatment was (69.89±12.07) and (26.62±20.23) respectively.The results showed that the difference of mean constipation score before the treatment was not statistically significant (t=0.482,P=0.63) between the two groups,but difference was statistically significant between the two groups after the treatment (t=-4.12,P<0.05),treatment group was significantly better than control group in reducing the constipation scores.There was no statistically significant difference in abdominal pain (Z =-1.96,P > 0.05),diarrhea (Z =-1.97,P> 0.05),and vomiting (Z =-0.58,P> 0.05) between the two groups. Conclusions Senna granules can be effective in the treatment of opioid-induced constipation and opioid-induced other mild side effects. |
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