| 王冰,黄焕森,李长科.瑞芬太尼用于哺乳期妇女胃镜检查的麻醉对血浆泌乳素水平的影响[J].安徽医药,2017,21(10):1906-1908. |
| 瑞芬太尼用于哺乳期妇女胃镜检查的麻醉对血浆泌乳素水平的影响 |
| Effect of Remifentanil on prolactin levels in plasma of lactating women for painless gastroscopyWANG Bing1,HUANG Huansen2,LI Changke1 (1.Department of Anesthesiology,Yuebei People′s Hospital,Shaoguan,Guangdong 512026；2.Department of Anesthesiology,Second Affliliated Hospital of Guangzhou Medical College,Guangzhou,Guangdong 510260) Abstract:Objective |
| 投稿时间：2016-06-20 |
| DOI： |
| 中文关键词: 瑞芬太尼 无痛胃镜 泌乳素 |
| 英文关键词: Remifentanil Painless gastroscopy Prolactin |
| 基金项目: |
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| 中文摘要: |
| 目的 观察瑞芬太尼联合丙泊酚对哺乳期妇女无痛胃镜检查中血流动力学、血浆泌乳素水平、复苏时间及不良反应的影响。 方法 选择90例哺乳期女性患者,美国麻醉医师协会(ASA)Ⅰ～Ⅱ级,将90例采用随机数字表法分为瑞芬太尼复合丙泊酚麻醉组(R组) ,芬太尼复合丙泊酚麻醉组(F组)和普通胃镜组(O组),每组各30例。记录三组患者麻醉开始前(T0)、检查开始前(T1)、胃镜过会厌时(T2)、胃镜退出时(T3)四个时间点的心率(HR)、平均动脉压(MAP)、血氧饱和度(SpO2)；记录患者苏醒时间、离院时间及苏醒过程中恶心呕吐、头晕不良反应的发生率；抽血检测麻醉开始前(T0)、胃镜退出时(T3)及检查结束后24 h(T4)血浆泌乳素水平。 结果 与T0相比,R组与F组患者在T1时间点MAP、HR、SpO2明显降低(P<0.05)。T2、T3时间点MAP、HR、SpO2与T0比较,差异无统计学意义(P>0.05)；而O组患者在 T2、T3时间点MAP、HR与T0相比明显升高,差异有统计学意义(P<0.05)；R组患者苏醒时间与离院时间较F组明显缩短(P<0.05)；R组与F组患者在T3时间点血浆泌乳素水平远远高于O组(P<0.05),但R组与F组组间比较差异无统计学意义(P>0.05)；R组检查结束后头晕、困倦感的发生率显著低于F组(P<0.05)。 结论 瑞芬太尼和芬太尼分别复合丙泊酚用于胃镜检查的麻醉均能有效抑制操作引起的应激反应,但瑞芬太尼能明显缩短苏醒时间和离院时间,提高苏醒质量,并且对血清泌乳素水平无不良影响,更适合哺乳期女性患者。 |
| 英文摘要: |
| Objective To observe the influences of remifentanil combined with propofol on hemodynamics,recovery time and plasma prolactin levels in lactating women receiving painless gastroscopy. Methods 90 patients (ASAⅠ-Ⅱ) receiving gastroscopy were divided into three groups:Group remifentanil (R group,n=30),Group fentanyl (F group,n=30) and Group ordinary gastroscopy (O group,n=30).MAP,HR,SpO2 of all patients before anesthesia,before the checking,the time of the gastroscope through the epiglottis,at the end of endoscopy were recorded.Recording recovery time of patient,plasma prolactin levels of before anesthesia,the end of endoscopy and 24 h after checking. Results MAP,HR,SpO2 of Rgroup and Fgroup patients after anesthetic decreased transiently,but within the normal range.MAP,HR of Ogroup patients increased significantly during the endoscopy；period of recovery and away from the recovery room of group Rwas significantly shorter than F；plasma prolactin levels of Group Rand Group Fat the end of endoscopy were much higher than Group O. Conclusions Remifentanil and fentanyl combined with propofol used for gastroscopy can effectively inhibit the stress response caused by the operation.However,remifentanil can significantly decrease the duration of the recovery,with no effect on PRL levels,which suitable for lactating patients. |
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