| 徐秀理,卢虎生,胡宗涛,等.国内伽玛刀与手术治疗三叉神经痛疗效的Meta分析[J].安徽医药,2017,21(11):2042-2045. |
| 国内伽玛刀与手术治疗三叉神经痛疗效的Meta分析 |
| Efficacy and safety of gamma-knife vs.neurosurgical interventions for patients with trigeminal neuralgia in China:A Meta-analysis |
| 投稿时间：2016-12-28 |
| DOI： |
| 中文关键词: 伽玛刀 手术治疗 三叉神经痛 Meta分析 |
| 英文关键词: Gamma-knife Neurosurgical intervention Trigeminal neuralgia Meta-analysis |
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| 摘要点击次数: 2066 |
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| 中文摘要: |
| 目的 评价伽玛刀(GKS)治疗与手术治疗三叉神经痛(TN)的疗效及安全性。方法 计算机检索PubMed、中国生物医学文献数据库、中国期刊全文数据库及万方数据库,纳入GKS治疗与手术治疗TN的随机对照试验(RCT),检索时间截止于2012年12月,由2名评价者按照纳入和排除标准独立选择文献,提取资料并评价质量。采用Stata 11.0软件进行Meta分析。结果 最终纳入系统评价的1篇完全RCT文献和4篇回顾性队列研究,纳入患者564例(GKS组293例,手术组271例)。对TN疼痛缓解疗效的分析(OR=0.56,95%CI=0.06～5.64,P=0.625),两组间差异无统计学意义。治疗后面部麻木的分析(OR=0.39,95%CI=0.08～1.91,P=0.243),复发情况分析(OR=1.59,95%CI=0.68～3.73,P=0.287),两组间差异无显著性,其他并发症分析(OR=0.30,95%CI=0.15～0.62,P=0.001),两组间差异有统计学意义。结论 GKS与手术治疗TN在对疼痛的有效率、治疗后面部麻木情况、复发情况方面差异无统计学意义,但在改善治疗后其他并发症方面GKS较手术治疗TN存在显著优势。 |
| 英文摘要: |
| Objective To evaluate the efficacy and safety of gamma-knife in comparison with neurosurgical interventions in the treatment of trigeminal neuralgia in China. Methods Randomized controlled trials (RCTs) data about gamma-knife vs.neurosurgical interventions for patients with trigeminal neuralgia were collected by Pubmed,Chinese biomedical literature (CBM) database,Chinese journal full-text database (CNKI) and Wanfang database,the retrieval time of RCTs ended in December 2012.Stata 14.0 was applied for Meta-analysis.RCTs were selected,screened by two review authors according to the inclusion and exclusion criteria.The screened literatures were evaluated and Meta analyzed by Stata 11.0 software. Results One complete RCT article and five retrospective cohort studies that included 564 patients (GKS group included 293 cases,neurosurgical therapy group included 271 cases) were eligible for inclusion.The Meta-analysis showed that the trigeminal neuralgia remission effect of gamma-knife therapy group was similar with neurosurgical therapy group,the difference was not statistically significant (OR=0.56,5%CI 0.06-5.64,P=0.625)；the facial numbness after treatment (OR=0.39,5%CI 0.08-1.91,P=0.243)；the other complications of gamma-knife group was significantly lower than that of neurosurgical therapy group (OR=0.30,5%CI 0.15-0.62,P=0.001)；the recurrence rate after treatment (OR=1.59,5%CI 0.68-3.73,P=0.287). Conclusions Based on the available evidence,our results suggest that trigeminal neuralgia remission effect,facial numbness and recurrence rate of gamma-knife therapy have no significant differences.Gamma-knife radiosurgery therapy might be an effective and safe method in treating other complications for patients with trigeminal neuralgia in China. |
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