| 张柳,李香彭,张兰兰,等.降钙素原和C-反应蛋白水平在指导慢性阻塞性肺疾病急性加重期患者抗生素使用中的应用价值[J].安徽医药,2017,21(11):2046-2048. |
| 降钙素原和C-反应蛋白水平在指导慢性阻塞性肺疾病急性加重期患者抗生素使用中的应用价值 |
| Application value of procalcitonin and C-reactive protein level in guiding the use of antibiotic in patients with actue exacerbation of chronic obstructive pulmonary disease |
| 投稿时间：2017-01-22 |
| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 急性发作期 降钙素原 C-反应蛋白 抗生素 |
| 英文关键词: Chronic obstructive pulmonary disease Acute exacerbation Procalcitonin C-reactive protein Antibiotic |
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| 摘要点击次数: 2073 |
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| 中文摘要: |
| 目的 探讨血清降钙素原(PCT)在指导慢性阻塞性肺疾病急性加重期(AECOPD) 患者抗生素使用中的应用价值。方法 选取收治的120例AECOPD患者,随机分为PCT组(n=40)、C-反应蛋白(CRP)组(n=40)和对照组(n=40)。PCT组、CRP组分别根据血清PCT、CRP水平指导使用抗生素,对照组根据临床症状、体征等决定抗生素的使用。观察三组患者临床有效率、抗生素应用情况、住院时间、住院费用、二重感染等指标。结果 PCT组、CRP组、对照组治疗有效率分别为90.0%、87.5%、92.5%,差异无统计学意义(P＞0.05)；PCT组、CRP组在抗生素使用率、使用强度、使用时间及费用方面均较对照组低(P＜0.05)；在住院时间、住院费用方面,PCT组、CRP组均较对照组低(P＜0.05)。PCT组较CRP组抗生素使用率及使用强度更低(P＜0.05)。PCT组较对照组二重感染降低(P＜0.05)。PCT组与CRP组在抗生素使用时间、住院时间、住院费用方面差异无统计学意义(P＞0.05)。结论 血清PCT、CRP的水平在指导AECOPD患者抗生素使用中均有良好效果,对减少抗生素暴露有重要意义,但PCT的敏感性更高。 |
| 英文摘要: |
| Objective To investigate the application value of procalcitonin level in guiding the use of antibiotic in patients with actue exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods One hundred and twenty AECOPD patients which were admitted to Department of Pneumology,97th People′s Liberation Army Hospital from May 2014 to June 2016 were assigned into PCT group(n=40),C-reactive protein group(n=40) and control group(n=40).PCT group,CRP group guided the use of antibiotics according to serum PCT,CRP levels；the empirical group decided the use of antibiotics according to the clinical symptoms,signs.The clinical effective rate,antibiotic use rate,antibiotic treatment time,hospitalization time,hospitalization cost,double infection were observed. Results The effective rates of PCT group,CRP group,control group were 90.0%,87.5%,92.5%,respectively,with no significant difference(P>0.05).The antibiotic use rate,the use of strength and the number of days of PCT group,CRP group were lower than control group(P<0.05).The number of hospitalization and hospitalization expenses of PCT group and CRP group were lower than control group(P<0.05).The antibiotic use,antibiotic use intensity of PCT group were lower than CRP group(P<0.05).Compared with the control group,the secondary infection of PCT group was decreased(P<0.05).There were no significant differences in antibiotic use time,hospitalization time and hospitalization cost between PCT group and CRP group(P>0.05). Conclusions Serum PCT,CRP levels have a good effect on guiding the use of antibiotics in patients with AECOPD,which play an important role in reducing the exposure of antibiotics,while the sensitivity of PCT is higher. |
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