| 匡巍,余昌胤.磷脂酰肌醇-3磷酸激酶/AKT/雷帕霉素靶蛋白信号通路参与中枢神经损伤保护与修复的研究进展[J].安徽医药,2018,22(2):215-219. |
| 磷脂酰肌醇-3磷酸激酶/AKT/雷帕霉素靶蛋白信号通路参与中枢神经损伤保护与修复的研究进展 |
| Progress in the study of the PI3K/AKT/mTOR signaling pathway regulates central nervous damage protection and repair |
| 投稿时间：2017-07-28 |
| DOI： |
| 中文关键词: 中枢神经系统 损伤 磷脂酰肌醇-3磷酸激酶/AKT/雷帕霉素靶蛋白通路 |
| 英文关键词: central nervous damage PI3K/AKT/mTOR signaling pathway |
| 基金项目: |
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| 摘要点击次数: 3058 |
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| 中文摘要: |
| 中枢神经细胞对各种损伤刺激耐受差,损伤后神经修复困难。因此促进神经保护增强神经再生能力已成为神经治疗关键。磷脂酰肌醇-3磷酸激酶/AKT/雷帕霉素靶蛋白(PI3K/AKT/mTOR)信号通路是调节细胞周期的重要通路,在细胞增殖、生长、分化过程中起中心调控作用,在神经损伤过程中通过激活PI3K/AKT/mTOR信号通路可减少神经细胞死亡,促进神经修复。该文对PI3K/AKT/mTOR信号通路在中枢神经损伤保护作用、修复机制及可能风险作一综述,探讨将PI3K/AKT/mTOR信号通路作为靶点治疗中枢神经疾病。 |
| 英文摘要: |
| The central nerve cells are difficult to tolerate of various kinds of damage,and difficult repair after injury.Therefore,it is crucial to promote neural regeneration to nerve protection.The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle.It plays a central role in cell proliferation,growth and differentiation.The activation of the PI3K/AKT/mTOR signaling pathway can reduce the death of nerve cells and promote nerve repairduring nerve damage.This paper reviewed PI3K/AKT/mTOR signaling pathway in central nervous damage protection,repair mechanisms and possible risksas to exploreuse.The PI3K/AKT/mTOR signaling pathway as a target treatment of central nervous disease. |
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