| 王武明,谭静,彭娜.头孢硫脒对小儿重症肝炎并发感染的预防作用[J].安徽医药,2018,22(2):324-327. |
| 头孢硫脒对小儿重症肝炎并发感染的预防作用 |
| The concurrent infection prevention effect of cefathiamidine onchildren with severe hepatitisWANG Wuming,TAN Jing,PENG Na (Department of Pediatrics,Dazhou Central Hospital,Dazhou,Sichuan 635000,China) Abstract:Objective |
| 投稿时间：2016-11-10 |
| DOI： |
| 中文关键词: 头孢硫脒 小儿重症肝炎 感染 预防作用 |
| 英文关键词: cefathiamidine severe hepatitis infection preventive effect |
| 基金项目: |
|
| 摘要点击次数: 1956 |
| 全文下载次数: 577 |
| 中文摘要: |
| 目的 观察头孢硫脒对小儿重症肝炎并发感染的预防作用。 方法 70例重症肝炎患儿,按随机数字表法将其分为观察组和对照组各35例。两组患儿均给予保肝、利胆退黄、利尿等治疗,另给予观察组患儿头孢硫脒静脉滴注1周。记录并分析两组患儿治疗前后体内炎症水平、治疗后感染情况、感染部位分布以及治疗过程中的不良反应。 结果(1)观察组医院内感染比例、病死率、合并感染病死率分别为28.57%、25.71%、40.00%,低于对照组57.14%、51.43%、66.67%,差异有统计学意义(均P＜0.05)；(2)在感染部位的分布上,两组患者差异无统计学意义,均以腹膜炎和呼吸道感染为主；(3)观察组治疗后血浆白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平分别为(38.96±3.76)、(34.58±3.17) ng·L-1,低于对照组(49.39±4.38)、(42.16±3.87)ng·L-1,差异有统计学意义(均P＜0.05)；(4)观察组治疗后血浆白细胞水平和中性粒细胞比例分别为(8.97±0.59)×109 L-1、72.83%±2.71%,低于对照组(10.99±0.68)×109 L-1、78.68%±4.16%,差异有统计学意义(均P＜0.05)；(5)治疗过程中观察组患儿发生不良反应比例为11.43%,略高于对照组5.72%,但差异无统计学意义(χ2=0.729,P=0.393)。 结论 头孢硫脒可降低小儿重症肝炎并发感染的比例,改善重症肝炎患儿预后,且不会明显增加治疗过程中的不良反应。 |
| 英文摘要: |
| Objective To observe the concurrent infection prevention effect of cefathiamidine on children with severe hepatitis. Methods 70 children with severe hepatitis were randomly divided into observation group with 35 cases and control group with 35 cases.Two groups of children were given liver protection,gallbladder jaundice,diuretic therapy and observation group were given another cefathiamidine.The inflammation level,infection,distribution site of infection and adverse reactions during treatment were recorded and analyzed. Results(1)After treatment,the hospital infections proportion,mortality rate and mortality rate with infection mortality rate of observation group were 28.57%,25.71%,40.00%,which were better than the control group with 57.14%,51.43%,66.67%,and the differences were statistically significant (P＜0.05).(2) In the distribution of infected sites,the two groups of patients are not different (P＞0.05).The main infected sites were respiratory infections and peritonitis.(3) After treatment,the interleukin-6 (IL-6) level and tumor necrosis factor-α(TNF-α) level were(38.96±3.76),(34.58±3.17) ng·L-1,which were better than the control group with (49.39±4.38),(42.16±3.87) ng·L-1,and the differences were statistically significant (P＜0.05).(4) After treatment,the white blood cell level and neutrophil percentage were (8.97±0.59)×109 L-1,72.83 %±2.71%,which were better than the control group with (10.99±0.68)×109 L-1,78.68%±4.16%,and the differences were statistically significant (P＜0.05).(5) The adverse reactions of observation group during treatment was 11.43%,and compared to the control group 5.72%,the difference was not significant (χ2=0.729,P=0.393).Conclusions Cefathiamidine can effectively reduce complicated infection ratio in children with severe hepatitis and will not significantly increase the side effects. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
