| 韩晓娟,刘易慧,张静,等.1例华法林过度抗凝治疗的原因分析[J].安徽医药,2018,22(3):523-525. |
| 1例华法林过度抗凝治疗的原因分析 |
| Analysis of 1 case of warfarin overanticoagulant therapy |
| 投稿时间：2016-10-30 |
| DOI： |
| 中文关键词: 华法林 过度抗凝 遗传因素 环境因素 |
| 英文关键词: warfarin overanticoagulation genetic factors environmental factors |
| 基金项目: |
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| 中文摘要: |
| 目的 分析导致患者发生过度抗凝的可能原因,并指导临床用药。 方法 回顾病例资料,从遗传因素、环境因素等角度出发,查阅相关文献报道,探讨各因素与过度抗凝之间的相关性。 结果 患者VKORC1基因型为突变纯合型,华法林抗凝期间合并使用苯溴马隆、注射用头孢尼西钠、阿托伐他汀钙片,维生素K摄入量减少,合并肝功能异常、心力衰竭两种疾病状态,且存在华法林给药方案调整欠妥当的问题,以上因素均可能在一定程度上导致患者的过度抗凝治疗。 结论 临床药师应从遗传因素、环境因素各个角度出发,筛查发生过度抗凝的高危人群,及时给医生提出建议,减少过度抗凝的发生,促进临床用药安全。 |
| 英文摘要: |
| Objective To analyze the possible causes of overanticoagulation,and to provide reference for screening methods of overanticoagulation at high risk. Methods From the aspects of genetic factors and environmental factors,the related literatures were reviewed and the correlation between each factor and overanticoagulation was analyzed. Results VKORC1 genotype of the patient was mutant homozygote.The use of benzbromarone,cefonicid sodium for injection and atorvastatin during warfarin anticoagulation resulted in decreased vitamin Kintake,combined with liver dysfunction and heart failure,and there existed the inadequate adjustment of warfarin dose.All of the above factors were likely to participate in patients′ overanticoagulation. Conclusions Clinical pharmacists should screen overanticoaculation high-risk groups from genetic factors and environmental factors,and give doctors a feasible recommendation in a timely manner,to reduce overanticoaculation and promote safe drug usage. |
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