| 张莉,陈卫东,刘磊.慢性肾脏病与动脉粥样硬化的相关性及纤维蛋白原在其中的作用[J].安徽医药,2018,22(4):583-586. |
| 慢性肾脏病与动脉粥样硬化的相关性及纤维蛋白原在其中的作用 |
| The correlation between chronic kidney disease and atherosclerosis and the role of fibrinogen in it |
| 投稿时间：2016-12-26 |
| DOI： |
| 中文关键词: 慢性肾脏病 心血管疾病 动脉粥样硬化 纤维蛋白原 |
| 英文关键词: chronic kidney disease cardiovascular disease atherosclerosis fibrinogen |
| 基金项目:安徽省高等学校省级自然科学研究重点项目(kJ2013A191) 作者简介:张莉,女,硕士研究生 |
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| 中文摘要: |
| 慢性肾脏病(CKD)患者是动脉粥样硬化(AS)疾病及心血管疾病(CVD)的高危人群。CKD患者普遍存在凝血功能紊乱和纤溶系统异常,后者在AS的起始和进展中起着重要作用。纤维蛋白原(FIB)是人体中一项重要的凝血因子,有研究认为,高纤维蛋白原血症可以作为心血管事件的独立危险因素。CKD、AS及CVD三者之间存在密切关联,与多种途径有关,而FIB途径相关报道较少,该文将进行相关总结。 |
| 英文摘要: |
| Patients with chronic kidney disease(CKD) are at high risk of atherosclerosis and cardiovascular events.Disorder of coagulation and fibrinolysis,which play an important role in the initiation and progression of atherosclerosis,are common in patients with chronic kidney disease.Fibrinogen is an important coagulation factor in human body.It has been suggested that fibrinogen may be an independent risk factor for cardiovascular events.Chronic kidney disease,atherosclerosis and cardiovascular disease are closely related with each other and involving in various signal ways.In view of the reports concerned the FIB pathway are fewer,the related summary will be carried on in this article. |
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