| 何畏,鲁小莉,吴桂辉.吡嗪酰胺耐药对初治菌阳肺结核患儿疗效的影响[J].安徽医药,2018,22(5):958-960. |
| 吡嗪酰胺耐药对初治菌阳肺结核患儿疗效的影响 |
| Effect of PZA resistance on the treatment of pulmonary tuberculosis among children |
| 投稿时间：2016-11-01 |
| DOI： |
| 中文关键词: 肺结核 吡嗪酰胺 初治 耐药 小儿 |
| 英文关键词: pulmonary tuberculosis pyrazinamide initial treatment drug resistance children |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨吡嗪酰胺(PZA)耐药对初治菌阳肺结核患儿治疗的影响。方法 选取采用PZA初治菌阳肺结核患儿182例,根据药物耐受情况分为PZA敏感患者140例(敏感组),PZA耐药患者42例(耐药组),对比检测两组治疗2月末、6月末痰菌转阴情况,以及在治疗2月末行胸片X线检查。结果 敏感组和耐药组患者治疗前痰涂片、病灶范围和空洞情况比较差异无统计学意义(P＞0.05),耐药组治疗2月末涂片转阴和病灶吸收的比例分别为80.95%和69.05%,与敏感组比较差异无统计学意义(P＞0.05)；敏感组治疗2月末空洞缩小比例为70.64%,明显高于耐药组(P＜0.05)；耐药组治疗6月末痰菌转阴比例为90.48%,与敏感组比较差异无统计学意义(P＞0.05)。结论 PZA单耐药对患者2月末、6月末痰菌阴转率及病灶改善未见明显影响,但对肺结核空洞吸收有较显著影响,故要加强结核患者PZA耐药状况的检测。 |
| 英文摘要: |
| Objective Objective To investigate the effect of Pyrazinamide (PZA) drug resistance on the treatment of children with sputum positive initially treated pulmonary tuberculosis.Methods 182 cases of sputum positive initial treated pulmonary tuberculosi children were retrospectively selected,according to the drug tolerance into 140 cases were sensitive to PZA (sensitive group),42 patients with PZA resistant patients (resistant group),negative-cultured sputum at the end of the February,June treatment,chest X-ray examination at the end of the February treatment were comparatively detected between two groups.Results There was no significant difference in the sputum smear,the range of lesions and the cavity between the sensitive group and the drug resistant group (P＞0.05);the proportion of negative sputum smear and lesion absorption in resistant group at the end of the February treatment was 80.95% and 6.05%,compared with sensitive group no significant difference (P＞0.05);the proportion of cavity reducing in the sensitive group was 70.64% at the end of February treatment,which was significantly higher than that in resistant group,the difference was statistically significant (P＜0.05);the proportion of negative sputum smear in resistance group at the end of June treatment was 90.48%,compared with sensitive group no significant difference (P＞0.05).Conclusions PZA single drug resistance on the patients the sputum negative conversion rate and the improvement of the lesions are not significantly affect at the end of February,June treatment,but there is a significant impact on the absorption of pulmonary tuberculosiscavity,Therefore,it is needed to strengthen the detection of PZA drug resistance in patients with tuberculosis. |
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