| 谢万祥,黄金平.睾酮对慢性肾功能衰竭大鼠肾性贫血的影响及其作用机制[J].安徽医药,2018,22(8):1454-1456. |
| 睾酮对慢性肾功能衰竭大鼠肾性贫血的影响及其作用机制 |
| Effect of testosterone on renal anemia in rats with chronic renal failure and its mechanism |
| 投稿时间：2017-01-04 |
| DOI： |
| 中文关键词: 肾性贫血 睾酮 促红细胞生成素 铁调素 |
| 英文关键词: Renal Anemia Testosterone EPO Hepcidin |
| 基金项目:随州市卫生和计划生育委员会医学科研项目(2105SMR019) |
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| 中文摘要: |
| 目的 研究睾酮对慢性肾功能衰竭大鼠肾性贫血的治疗效果并探讨其作用机制。方法 24只雄性Wistar大鼠采用随机单位组设计组法分为:对照组(NC)、正常大鼠睾酮干预组(NT)、慢性肾功能衰竭大鼠组(CD)、慢性肾功能衰竭大鼠睾酮治疗组(CT)。CD、CT两组建立慢性肾功能衰竭大鼠模型,造模成功后NT、CT两组给予丙酸睾酮皮下注射,8周后处死大鼠,检测贫血指标及铁调素,促红细胞生成素(EPO)表达情况。结果 睾酮能显著升高慢性肾功能衰竭大鼠血红蛋白(Hb),血清铁(SI),总铁蛋白结合力(TIBC)表达,同时增加肾脏EPO的表达,降低肝脏内铁调素表达。结论 睾酮能显著纠正慢性肾功能衰竭大鼠肾性贫血,其机制可能与上调EPO表达、减弱铁调素作用相关。 |
| 英文摘要: |
| Objective To observe the effects of testosterone in the treatment of renal anemia with chronic renal failure in rats and explore the possible mechanism. Methods 24 male Wistar rats were randomly divided into four groups, normal control group (NC), normal treatment group (NT), chronic kidney disease group (CD), chronic kidney disease treatment group (CT). Chronic kidney disease model were established in CD, CT groups. NT, CT groups were given the testosterone by subcutaneous injection. After 8 weeks, measuring blood routine and SI, TIBC, Western blot were performed to examine the expression of EPO and hepcidin. Results The HB, SI, TIBC in NT, CT groups were increased significantly. Compared with CD group, EPO protein expression increased in CT group while hepcidin decreased. Conclusion Testosterone can treat renal anemia effectively. which protective function may associated with the decrease expression of hepcidin and increase expression of EPO. |
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