| 蔡莉莉,郝维敏,夏宏林.淋巴细胞亚群检测在小儿过敏性紫癜诊治中的应用[J].安徽医药,2018,22(8):1507-1510. |
| 淋巴细胞亚群检测在小儿过敏性紫癜诊治中的应用 |
| Clinical significance of diagnosis and treatment of lymphocyte subsets in children with Henoch-Schonlein purpura |
| 投稿时间：2017-05-30 |
| DOI： |
| 中文关键词: 淋巴细胞亚群检测 过敏性紫癜 抗溶血性链球菌O 儿童 |
| 英文关键词: Detection of lymphocyte subsets Henoch-schonlein purpura Hemolytic streptococcus O Children |
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| 中文摘要: |
| 目的 探讨淋巴细胞亚群检测在小儿过敏性紫癜(HSP)诊治中的作用及意义。方法 选取73例HSP患儿作为HSP组,并根据是否感染溶血性链球菌分为链球菌感染组(31例)和链球菌未感染组(35例),并设同期正常体检的30例儿童为健康对照组。分析两组患儿入院时及采用相同治疗方案2周后的临床症状和淋巴细胞亚群检测结果。结果 与健康对照组比较,HSP组存在CD4+[33.572±7.408)%比(37.225±5.789)%]、 CD4+/CD8+[1.270±0.218)%比(1.582±0.176)%]及CD16+CD56+[12.301±4.946)%比(15.553±4.249)%]细胞比值下降,CD8+[29.887±5.538)%比(24.500±3.589)%]、CD19+[20.603±4.713)%比(14.100±3.699)%]细胞比值上升,差异有统计学意义(P<0.05)。治疗2周后,链球菌感染组患儿淋巴细胞亚群检测数值及临床症状改善均不明显,而链球菌非感染组患儿的淋巴细胞亚群数值和临床症状明显改善,差异有统计学意义(P<0.05)。 结论 HSP患儿急性期存在细胞免疫紊乱,溶血性链球菌感染会进一步加重该类患者细胞免疫功能紊乱,淋巴细胞亚群检测对小儿HSP诊治具有重要的作用与意义。 |
| 英文摘要: |
| Objective To investigate the change of lymphocyte subsets in children with Henoch-Schonlein purpura and beneficial for clinical care.Methods Seventy-three cases of Henoch-Schonlein purpura were divide into infected and uninfected groups with hemolytic streptococcus. Compared with 30 normal children, the lymphocyte data and clinical symptoms at admission and after two weeks’ treatment were analyzed.Results Compared to the normal control group, the number of CD4+[33.572±7.408)% vs. (37.225±5.789)%], the ratio of CD4+/CD8+[1.270±0.218)% vs. (1.582±0.176)%] and CD16+CD56+[12.301±4.946)% vs. (15.553±4.249)%] were all decreased. The number of CD8+[29.887±5.538)% vs. (24.500±3.589)%]and CD19+[20.603±4.713)% vs. (14.100±3.699)%] were increased (P<0.05). At admission, the number of CD19+ of infected group was higher than uninfected group,and the number of patients with hematuresis and proteinuria were higer than uninfected group. After two weeks’ treatment, there was no obviously improved about the lymphocyte data and clinical symptoms of infected group,while uninfected group improved (P<0.05).Conclusion Cellular immune disorders in the acute phase of HSP, hemolytic streptococcal infection can further aggravate the cellular immune disorders. Diagnosis and treatment of lymphocyte subsets are with great significance in children with HSP. |
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