| 徐晶,王晓峰.根除幽门螺杆菌对2型糖尿病患者血糖控制和机体微炎症反应的影响[J].安徽医药,2018,22(12):2400-2403. |
| 根除幽门螺杆菌对2型糖尿病患者血糖控制和机体微炎症反应的影响 |
| Effect of helicobacter pylori eradication on glycemic control and micro inflammation in type 2 diabetics complicated with asymptomatic helicobacter pylori infection |
| 投稿时间：2017-04-21 |
| DOI： |
| 中文关键词: 幽门螺杆菌 2型糖尿病 实时动态血糖监测系统 炎症因子 |
| 英文关键词: Helicobacter pylori (HP) Type 2 diabetes mellitus Continuous glucose monitoring system (CGMS)I Inflammatory factors |
| 基金项目: |
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| 中文摘要: |
| 目的 观察根除幽门螺杆菌(HP)治疗对无症状HP感染的2型糖尿病患者血糖控制和机体微炎症反应的影响。 方法选取南京市红十字医院就诊的2型糖尿病患者383例,分为无HP感染者142例,无症状HP感染未行根除HP治疗者72例,无症状HP感染并接受根除HP治疗者169例。应用胰岛素泵进行强化治疗,连续动态血糖监测系统进行监测,观察根除HP治疗对血糖控制和炎症因子超敏C-反应蛋白、肿瘤坏死因子-α、白细胞介素-8水平的影响。 结果 无症状HP感染并行根除HP治疗组,其总体血糖控制水平与未行根除HP治疗组相比,血糖水平控制好,夜间低血糖事件少,血糖达标所需的治疗时间短,胰岛素用量少,血糖波动不明显,血浆超敏C-反应蛋白、白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α、VCAM-1水平较低。 结论 根除HP治疗有助改善无症状HP感染的2型糖尿病患者血糖控制,降低机体炎症因子的水平。 |
| 英文摘要: |
| Objective To observe the effect of helicobacter pylori (HP) eradication on glycemic control and micro inflammation with type 2 diabetes mellitus complicated with HP infection. Methods A total of 383 patients with type 2 diabetes mellitus from our hospital were enrolled and divided into three groups:non-HP infection;HP infection without eradication;HP infection with eradication.Insulin pump intensive therapy and continuous glucose monitoring system were adopted in all patients.Effect of eradication of HP therapy on glycemic control and inflammatory factors of high sensitivity C-reactive protein,tumor necrosis factor alpha and interleukin -8 level were observed during the one month treatment. Results In HP infection with eradication group,overall level of glycemic control was better, and with less nocturnal hypoglycemic events,shorter treatment time of blood glucose reaching target,less dose of insulin and weaker glucose variability,as well as lower level of plasma high-sensitivity C- reactive protein,interleukin-8 and tumor necrosis factor alpha. Conclusion HP eradication can improve glycemic control and decrease inflammatory factors in type 2 diabetes mellitus patients complicated with asymptomatic HP infection during insulin pump intensive therapy. |
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