| 黄丽,罗圣平,谭秋红.73例普瑞巴林不良反应的文献分析[J].安徽医药,2019,23(2):421-424. |
| 73例普瑞巴林不良反应的文献分析 |
| Literature analysis of 73 cases of adverse drug reactions by Pregabalin |
| 投稿时间：2017-09-12 |
| DOI： |
| 中文关键词: 药品不良反应 普瑞巴林 文献分析 |
| 英文关键词: Adverse drug reaction Pregabalin Literature analysis |
| 基金项目: |
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| 中文摘要: |
| 目的 分析普瑞巴林不良反应发生情况及特点,为其临床合理使用提供参考。方法 检索2004年12月至2017年5月国内外医药期刊公开报道的普瑞巴林致不良反应个案报道,并进行统计分析。结果 纳入普瑞巴林致不良反应个案共73例,病人年龄主要集中在＞60~70岁(19.18%)；用药后1周~1个月内出现不良反应的例数最多(20例,27.40%)；普瑞巴林致不良反应累及器官/系统以中枢神经系统为主(31.25%)；主要临床表现为眩晕、嗜睡等。结论 临床使用普瑞巴林时,应关注病人年龄、既往史、肾功能及给药剂量。从小剂量开始给药,缓慢加药并严密监测,确保用药安全。 |
| 英文摘要: |
| Objective To analyze the occurrence and characteristics of the adverse reactions (ADRs) of Pregabalin,and to provide a reasonable reference for its clinical use.Methods Literatures of Pregabalin-induced ADRs reported in domestic and overseas pharmaceutical journals from December 2004 to May 2017 were retrieved and analyzed.Results A total of 73 ADR cases were induced by Pregabalin,and the age of patients were mainly ＞60 to 70 years old (19.18%).Most ADRs occurred within 1 week and 1 month of medication (20 cases,27.40%).Organs/systems involved in Pregabalin-induced ADRs were mainly the central nervous system (31.25%).The main clinical manifestations were dizziness and somnolence etc.Conclusions Importance should be attached to the patient's age,medical history,renal function and dosage when Pregabalin is used in clinics.Also we should start from a small dose,add dosing gradually and carry out close monitoring to ensure safety in medication. |
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