| 穆金兴,李雪霞,李延鑫,等.比伐卢定对ST段抬高型心肌梗死病人急诊介入治疗术后超敏C反应蛋白、脂蛋白相关磷脂酶A2、白细胞介素-4水平的影响[J].安徽医药,2019,23(3):601-604. |
| 比伐卢定对ST段抬高型心肌梗死病人急诊介入治疗术后超敏C反应蛋白、脂蛋白相关磷脂酶A2、白细胞介素-4水平的影响 |
| The effect of bivalirudin on hs-crp,Lp-PLA2 and IL-4 levels in patients with STEMI |
| 投稿时间：2017-09-11 |
| DOI： |
| 中文关键词: 比伐卢定可有效降低STEMI病人PCI术后hs-CRP、Lp-PLA2、IL-4水平,改善病人心功能,同时有利于降低MACE发生率以及出血事件发生率。 关键词:ST段抬高型心肌梗死 急诊介入治疗术 超敏C反应蛋白 脂蛋白相关磷脂酶A2 白细胞介素-4 |
| 英文关键词: ST segment elevation myocardial infarction Emergency interventional therapy Hypersensitive c-reactive protein Lipoprotein related phospholipase A2 Interleukin-4 |
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| 目的 研究比伐卢定对ST段抬高型心肌梗死(STEMI)病人急诊介入治疗(PCI)术后超敏C反应蛋白(hs-CRP)、脂蛋白相关磷脂酶A2(Lp-PLA2)、白细胞介素-4(IL-4)水平的影响。 方法 选取2015年2月至2017年2月于邢台市第三医院接受PCI术治疗的STEMI病人100例。根据病人术中所用抗凝药物种类不同分为观察组与对照组,每组50例。观察组则采用比伐卢定进行抗凝,对照组采用普通肝素进行抗凝。分别比较两组治疗前与治疗3 d后血清hs-CRP、Lp-PLA2、IL-4水平,治疗前与治疗30 d后心功能指标水平,MACE发生情况以及出血事件发生情况。 结果 治疗3 d后两组病人血清hs-CRP、Lp-PLA2、IL-4水平均明显低于治疗前,而观察组hs-CRP、IL-4水平分别为(22.7±5.4)mg/L、(2.0±0.5)pg/mL,均明显低于对照组的(32.8±5.6)mg/L、(3.7±0.9)pg/mL,均差异有统计学意义(均P＜0.05)。治疗30 d后观察组LVEF水平为(46.8±3.9)%,明显高于对照组的(43.2±4.0)%,而BNP水平为(284.5±113.8)ng/L,明显低于对照组的(462.8±103.7)ng/L,均差异有统计学意义(均P＜0.05)。治疗30 d后观察组病人MACE发生率为2.00%(1/50),明显低于对照组的14.00%(7/50),差异有统计学意义(P＜0.05)。观察组出血事件发生率为4.00%(2/50),明显低于对照组的18.00%(9/50),差异有统计学意义(P＜0.05)。 |
| 英文摘要: |
| Objective To study the effect of Bivalirudin on postoperative hypersensitive c-reactive protein (hs CRP) and lipoprotein associated phospholipase A2 (Lp-PLA),interleukin 4 (IL-4) level in patients with ST segment elevation myocardial infarction(STEMI) emergency intervention (PCI). Methods 100 cases of STEMI patients treated with PCI were selected from February 2015 to February 2017.According to the types of anticoagulants used,patients were divided intothe research group and the control group,with 50 patients in each group.The research group was given anticoagulant,while the control group was given normal heparin for anticoagulation.The serum hs-CRP,Lp-PLA2 and IL-4 levels were compared before and after treatment,before treatment and treatment of 30 d core function indexes,the occurrence of MACE and the occurrence of bleeding events. Results After treatment for 3 d,hs-CRP serum of two groups of patients,Lp-PLA2,IL-4 levels were significantly lower than those before the treatment.The research group hs-CRP,IL-4 levels respectively(22.7±5.4) mg/L,(2.0±0.5) pg/mL,were significantly lower than those in the control group (32.8±5.6) mg/L,(3.7±0.9) pg/mL,differences were statistically significant (all P ＜ 0.05).LVEF level for 30 d after treatment in the research group was(46.8±3.9)%,significantly higher than that of control group (43.2±4.0)%,and BNP level for (284.5±113.8) ng/L,significantly lower than that of the control group (462.8±103.7) ng/L,which had statistically significant differences (all P＜0.05).After treatment of 30 d,MACE of the research group was 2.00%(1/50),significantly lower than that of the control group of 14.00%(7/50),and the difference had statistically significant(P＜0.05.The incidence of haemorrhage in the research groupwas 4.00%(2/50),significantly lower than that in the control group of 18.00%(9/50),and the difference had statistically significant(P＜0.05). Conclusion Compared with fvaru,the hs-crp,Lp-PLA2 and IL-4 levels in the PCI postoperatively of STEMI patients can be effectively reduced,and the cardiac function of patients can be improved,and the incidence of MACE and the incidence of bleeding events can be reduced. |
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