| 李磊,陈咏梅,张宏考.肥胖对冠心病病人阿托伐他汀降脂疗效的影响[J].安徽医药,2019,23(4):710-712. |
| 肥胖对冠心病病人阿托伐他汀降脂疗效的影响 |
| Effect of the lipid lowering effect of atorvastatin in patients with coronary heart disease |
| 投稿时间：2017-10-10 |
| DOI： |
| 中文关键词: 冠心病 肥胖症 治疗结果 阿托伐他汀 |
| 英文关键词: Coronary disease Obesity Treatment outcome Atorvastatin |
| 基金项目: |
|
| 摘要点击次数: 1877 |
| 全文下载次数: 530 |
| 中文摘要: |
| 目的 探讨肥胖对冠心病病人阿托伐他汀降脂疗效的影响。方法 选取2015年6月至2016年9月在咸阳市第一人民医院心血管住院诊治的伴有肥胖的冠心病150例作为试验组,另选取同期在同一科室住院诊治正常体型的冠心病病人100例作为对照组。根据入选及排除标准,给予入选病人阿托伐他汀降脂药物(每晚20 mg),最终完成6个月随访且入组的研究对象试验组139例,对照组79例。根据研究对象的体质量指数分为正常体型组(对照组)、超重组及肥胖组。三组间的血脂达标率差异性用χ2检验,任意两组间的比较用Bonferroni法；血脂是否达标与体型的关系采用logistic回归分析计算优势比。结果 三组间任意两组间的一般资料差异无统计学意义(P>0.05)；三组间(正常体型组、超重组、肥胖组)血脂达标率分别为82.3%、65.4%、55.2%,差异有统计学意义(P=0.002),与正常体型组相比,超重组、肥胖组的血脂达标率较低,且均差异有统计学意义(P=0.019、P=0.001),超重组、肥胖组的血脂达标率差异无统计学意义(P=0.290)；logistic回归分析结果示:与正常体型组相比超重组、肥胖组的优势比分别为0.408和0.265(P=0.016、P=0.009)。结论 冠心病人群中肥胖与阿托伐他汀药物的降脂疗效有关系,肥胖影响冠心病病人阿托伐他汀降脂药物的达标率。 |
| 英文摘要: |
| Objective To investigate the effect of the lipid lowering effect of atorvastatin in patients with coronary heart disease.Methods A total of 150 obesity patients with coronary heart disease in the First People's Hospital of Xianyang City from June 2015 to September 2016 were enrolled in this study as the experimental group,100 coronary heart disease patients with normal weight who were hospitalized and treated in the same department at the same time were selected as the control group.According to the selection and exclusion criteria,the selected patients were given atorvastatin drugs (20 mg per night) and 6 months follow-up,the group of subjects in the experimental group is 139 cases,the control group is 79 cases.According to the body mass index of the subjects,the subjects were assigned into normal body group (the control group),overweight group and obese group.The difference between the three groups of blood lipid compliance rate was compared by χ2 test,any comparison between the two groups using Bonferroni method;the relationship between blood lipid and body size was calculated by logistic regression analysis.Results There was no significant difference in the general data between any two groups(P>0.05);the overall compliance rate of blood lipid in normal body group,overweight group and obese group was 82.3%,65.4% and 55.2%,respectively,and the difference was significant.Compared with the normal body group,the blood lipid compliance rate of the overweight group and the obese group were lower,and the difference was statistically significant (P=0.019,P=0.001).There was no significant difference in the compliance rate of blood lipid between the overweight group and the obese group (P=0.290).Logistic regression analysis showed that the superiority ratio of the overweight group and the obese group were 0.408 and 0.265 respectively compared with the normal body group (P=0.016,P=0.009).Conclusion There was relation between obesity and effect of atorvastatin in coronary heart disease,obesity affect the compliance rate of atorvastatin in patients with coronary heart disease. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
