| 王哲,刘丹,于波心,等.某院肺炎链球菌感染的临床分布及耐药性分析[J].安徽医药,2019,23(6):1250-1253. |
| 某院肺炎链球菌感染的临床分布及耐药性分析 |
| Analysis of clinical distribution and drug resistance of Streptococcus pneumonia in a hospital |
| 投稿时间：2017-06-27 |
| DOI： |
| 中文关键词: 肺炎链球菌 临床分布 耐药性 |
| 英文关键词: Streptococcus pneumonia Clinical distribution Drug resistance |
| 基金项目: |
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| 中文摘要: |
| 目的 了解该院肺炎链球菌的临床分布及耐药性,为临床医师选择合理的抗感染治疗方案提供参考依据。方法 收集2012年1月至2015年12月中国医科大学附属盛京医院住院的病人为研究对象,按照美国临床实验室标准化委员会推荐的方法进行肺炎链球菌的初步筛选,用VITEK 2 Compact和VITEK MS进行细菌鉴定和药敏实验,用Excel进行数据统计分析。结果 2012—2015年共分离出292株肺炎链球菌,主要分布于儿科,共211株；主要来源于痰液标本,共115株。感染人群主要为5岁以下及50岁以上的病人。药敏结果显示肺炎链球菌对红霉素、四环素、青霉素G(脑膜炎)具有较高的耐药性,耐药率依次为96.77%、90.46%、80.85%；万古霉素、利奈唑胺和莫西沙星对肺炎链球菌具有良好的抗菌活性,耐药率依次为0.00%、0.34%、0.37%。结论 临床上肺炎链球菌感染的高发人群为5岁以下及50岁以上的病人,并且对多种抗菌药物都有很强的耐药性,应加强病原菌培养及耐药性监测,指导临床医师合理使用抗菌药物。 |
| 英文摘要: |
| Objective To explore the clinical distribution and drug resistance of Streptococcus pneumonia (SP),so as to provide references for rational use of antibiotics.Methods The patients hospitalized in the Shengjing Hospital of China Medical University from January 2012 to December 2015 were enrolled in the study.The preliminary screening of Streptococcus pneumonia was conducted according to the guideline of Clinical and Laboratory Standards Institute (CLSI).VITEK 2 Compact and VITEK MS were used to analyze the bacteria identification and drug sensitivity test,and Excel was used for statistical analysis.Results Totally 292 strains of Streptococcus pneumonia were isolated from 2012 to 2015,mainly found from the Department of Pediatrics with a total of 211 strains,and mainly from sputum specimens with a total of 115 strains.Infected people were mainly under 5 years old and over the age of 50.The susceptibility tests showed that SP has higher resistance to Erythromycin,Tetracycline and Penicillin G (Meningitis) with rates of 96.77%,90.46% and 80.85% respectively.Vancomycin,Linezolid and Moxifloxacin showed excellent antibacterial activity against SP with the drug resistance rates of 0.00%,0.34% and 0.37% respectively.Conclusion The Streptococcus pneumonia strains were mainly isolated from patients under 5 years old and over the age of 50,and they were highly resistant against various antibiotics.More attention should be paid to the bacterial culture and the monitoring of the drug resistance to direct clinical rational use of antibiotics for patients. |
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