| 董天慧,孙建梅,姚舜,等.波动性高糖对糖尿病视网膜病变的作用研究进展[J].安徽医药,2019,23(8):1485-1488. |
| 波动性高糖对糖尿病视网膜病变的作用研究进展 |
| Research progress on the effect of high glucose fluctuations on the pathogenesis of diabetic retinopathy |
| 投稿时间：2018-02-09 |
| DOI： |
| 中文关键词: 糖尿病视网膜病变 血管内皮生长因子类 细胞凋亡 自噬 氧化性应激 DNA损伤 波动性高糖 综述 |
| 英文关键词: Diabetic retinopathy Vascular endothelial growth factors Apoptosis Autophagy Oxidative stress DNA damage High glucose fluctuations Review |
| 基金项目: |
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| 摘要点击次数: 2279 |
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| 中文摘要: |
| 糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病微血管严重并发症之一,其发生发展不仅与长期的高血糖水平有关,而且与血糖波动幅度呈现明显正相关。波动性高糖通过启动细胞自噬和细胞凋亡,激活氧化应激,损伤视网膜组织DNA,促进血管内皮生长因子(vascular endothelial growth factor,VEGF)的释放等多种途径参与DR的发生进展。 |
| 英文摘要: |
| Diabetic retinopathy (DR) is one of the most serious diabetic microvascular complications.Its development and progression is not only related to long-term hyperglycemia,but also positively correlated with blood glucose fluctuations.High glucose fluctuations contribute to diabetic retinopathy through the following ways:inducing autophagy and apoptosis,activating oxidative stress,damaging DNA in retinal tissue cells,promoting the release of vascular endothelial growth factor (VEGF).This article is a brief review of contribution of high glucose fluctuations to DR. |
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