| 曹娟,黄书才,戴媛媛,等.精神分裂症住院病人应用阿立哌唑致锥体外系症状的影响因素[J].安徽医药,2019,23(10):2104-2107. |
| 精神分裂症住院病人应用阿立哌唑致锥体外系症状的影响因素 |
| The influence factors of aripiprazole?induced extrapyramidal symptoms in patients with schizophrenia |
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| DOI：10.3969/j.issn.1009?6469.2019.10.051 |
| 中文关键词: 精神分裂症 阿立哌唑 /副作用 锥体外束 影响因素分析 |
| 英文关键词: Schizophrenia Aripiprazole/adverse effects Extrapyramidal tracts Root cause analysis |
| 基金项目:芜湖市科技成果转化项目( 2018cg 11) |
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| 摘要点击次数: 1902 |
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| 中文摘要: |
| 目的探讨阿立哌唑治疗精神分裂症病人时锥体外系症状( EPS)的发生率及相关影响因素。方法选取 2014年 3月至 2018年 12月于芜湖市第四人民医院 309例单独服用阿立哌唑治疗的精神分裂症病人作为纳入对象，通过其资料进行回顾性研究，收集人口学特征、临床特征及用药情况等，将其分为 EPS组和非 EPS组进行比较，采用 logistic分析相关影响因素。结果所有纳入病人中 EPS的发生率为 17.80%。EPS组与非 EPS组在年龄［(31.75±9.52)岁比( 36.84±12.92)岁， Z＝3.353，P＝0.001］、病程［ 50(14，98)月比 72(25，132)月， Z＝2.807，P＝0.005］、最大服药剂量［(19.82±4.51)mg比( 17.93±3.29)mg，Z＝2.943，P＝ |
| 英文摘要: |
| Objective To investigate the incidence and influence factors of aripiprazole?induced extrapyramidal symptoms(EPS) in patients with schizophrenia.Methods The demographic characteristics，clinical features and drug application of 309 patients with schizophrenia treated with aripiprazole alone at The Fourth People’s Hospital of Wuhu from March 2014 to December 2018were collected retrospectively for the study.They were assigned into EPS group and non?EPS group，then the influence factors were analyzed by logistic analysis.Results The incidence of EPS in all patients was 17.80%.There were significant differences in terms of age［( 31.75±9.52)years old vs.(36.84±12.92)years old，Z＝3.353，P＝0.001］，duration of disease［50(14，98)months vs. 72(25，132)months，Z＝2.807，P＝0.005］，maximum dose［(19.82±4.51)mg vs.(17.93±3.29)mg，Z＝2.943，P＝0.004］，dosage per ki? logram of body weight［( 0.344±0.086)mg vs.(0.294±0.057)mg，Z＝4.120，P＜0.001］and medication season(χ2＝16.88，P＝ 0.001)between the two groups.The binomial logistic regression analysis showed that age and previous use of antipsychotic drugswere negatively correlated with the occurrence of EPS significantly(OR＝0.953，P＝0.003；OR＝0.279，P＝0.001)，and there was a significant positive correlation between the maximum dose and the dosage per kilogram of body mass and the occurrence of EPS(OR＝1.114，P＝0.034；OR＝3.875，P＝0.029).The EPS risk due to drug use was also increased significantly in summer(P＜ |
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