| 袁国龙,徐亮,牛林,等.大剂量羟氯喹治疗系统性红斑狼疮并发难治性血小板减少 1例[J].安徽医药,2019,23(11):2291-2293. |
| 大剂量羟氯喹治疗系统性红斑狼疮并发难治性血小板减少 1例 |
| High dose hydroxychloroquine treat a patient with systemic lupus erythematosus complicated with refractory thrombocytopenia |
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| DOI：10.3969/j.issn.1009?6469.2019.11.045 |
| 中文关键词: 红斑狼疮，系统性 血小板减少 羟氯喹 |
| 英文关键词: Lupus erythematosus,systemic Thrombocytopenia Hydroxychloroquine |
| 基金项目: |
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| 中文摘要: |
| 目的观察大剂量羟氯喹联合糖皮质激素治疗系统性红斑狼疮并发难治性血小板减少病人的治疗效果及其不良反应。方法 2010年 9月 13日收住阜阳市人民医院系统性红斑狼疮并发难治性血小板减少病人 1例，对大剂量糖皮质激素、丙种球蛋白以及多种免疫抑制剂治疗无效，应用大剂量羟氯喹(硫酸羟氯喹 0.6 g/d)联合糖皮质激素(醋酸泼尼松 20 m/d)治疗。结果大剂量羟氯喹联合激素对此例系统性红斑狼疮并发难治性血小板减少显示出良好的治疗效果并可以长期维持血小板数量，且未见明显不良反应发生。结论大剂量羟氯喹成功治疗 1例系统性红斑狼疮并发难治性血小板减少。 |
| 英文摘要: |
| Objective To observe the therapeutic effect and side effects of high dose hydroxychloroquine combined with glucocorti?coid in the treatment of a patient with systemic lupus erythematosus complicated with refractory thrombocytopenia. Methods A large dose of hydroxychloroquine(hydroxychloroquine sulfate 0.6 g daily)combined with glucocorticoid(prednisone acetate 20 mg daily)was used to treat a patient with refractory thrombocytopenia in systemic lupus erythematosus who resisted high?dose glucocor? ticoid，immunoglobulin and many immunosuppressants.Results High dose of hydroxychloroquine combined with glucocorticoid inthe treatment of systemic lupus erythematosus complicated with refractory thrombocytopenia showed a good effect and maintainedthe number of platelets for a long time without obvious adverse reactions.Conclusion A case of systemic lupus erythematosus com?plicated with refractory thrombocytopenia was successfully treated with high dose hydroxychloroquine. |
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