| 钱维娜,王莉莉,沈斌.缺血性脑卒中血清淀粉样蛋白 A表达水平及其与抑郁的相关性[J].安徽医药,2020,24(1):24-27. |
| 缺血性脑卒中血清淀粉样蛋白 A表达水平及其与抑郁的相关性 |
| Study on the expression of serum amyloid A and its correlation with depression in patients with ischemic stroke |
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| DOI：10.3969/j.issn.1009?6469.2020.01.007 |
| 中文关键词: 卒中 抑郁 血清淀粉样蛋白 A 社会学，医学 危险因素 高同种半胱氨酸血症 炎性反应 相关性 |
| 英文关键词: Stroke Depression Serum amyloid A protein Sociology,medical Risk factors Hyperhomocysteinemia Inflammatory reaction Relationship |
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| 摘要点击次数: 1885 |
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| 中文摘要: |
| 目的探讨缺血性脑卒中病人血清淀粉样蛋白 A(SAA)表达水平，以及 SAA与抑郁发生的关系。方法选择 2016年 6月至 2017年 12月启东市人民医院收治缺血性脑卒中 62例(研究组)、健康体检者 30例(对照组)，根据是否并发抑郁症将研究组分为脑卒中后抑郁( PSD)组( 15例)和非 PSD组( 47例)。比较不同组之间人口社会学、生活方式及生物学资料、影像学检查结果及 SAA、同型半胱氨酸( Hcy)水平变化，采用多因素 logistic回归分析缺血性脑卒中病人血清 SAA水平与抑郁的相关性。结果非 PSD组、 PSD组血清 SAA水平明显高于对照组［(167.55±23.18)比( 387.23±30.36)比( 104.20±14.27)μg/L(P＜0.05)］； PSD组血清 SAA水平、汉密尔顿抑郁量表( HAMD?17)评分均较非 PSD组明显升高( P＜0.05)。抑郁与非抑郁病人在性别、文化程度、高同型半胱氨酸血症( HHcy)、美国国立卫生研究院卒中量表( NIHSS)评分方面比较，均差异有统计学意义( P＜0.05)。性别( OR＝1.97，95%CI:1.29～2.98)、血清 SAA水平( OR＝3.25，95%CI:1.88～4.61)及 NIHSS评分( OR＝1.71，95%CI:1.14～ 2.54)是缺血性脑卒中病人并发 PSD的独立危险因素，而文化程度( OR＝0.23，95%CI:0.08～0.61)则是保护性因素( P＜0.05)。结论 SAA在缺血性脑卒中病人中明显升高，且与 PSD的发生密切相关，可作为预测 PSD发生的一种生物学标志物。 |
| 英文摘要: |
| Objective To explore the expression of serum amyloid A(SAA)and its correlation with depression in patients with ischemic stroke.Methods 62 patients with ischemic stroke(study group)and 30 healthy subjects(control group)admitted to Qi? dong People’s Hospital between June 2016 and December 2017 were selected.And study group was divided into PSD group(15 cases)and non?PSD group(47 cases)according to whether depression was complicated.Demographic sociology，lifestyle and biolog? ical data，imaging examination results and changes in SAA and homocysteine(Hcy)levels between different groups were compared.Multivariate logistic regression was used to analyze the correlation between SAA and the incidence of depression.Results Com? pared with control group，the level of serum SAA was significantly increased in non?PSD group and PSD group［( 167.55±23.18， 387.23±30.36 vs. 104.20±14.27)μg/L］，and the difference was statistically significant(P＜0.05).Compared with the non?PSD group，the level of serum SAA and HAMD score in PSD group were significantly increased(P＜0.05).There were statistically sig? nificant differences in gender，educational level，HHcy and NIHSS score between depressed and non?depressed patients(P＜0.05). Gender(OR＝1.97，95%CI:1.29?2.98)，serum SAA(OR＝3.25，95%CI:1.88?4.61)and NIHSS score(OR＝1.71，95%CI:1.14?2.54) were independent risk factors for PSD in patients with ischemic stroke，while education level(OR＝0.23，95%CI:0.08～0.61)was a protective factor(P＜0.05).Conclusion SAA is significantly increased in patients with ischemic stroke，and closely related to the occurrence of PSD，which can be used as a biological marker to predict the occurrence of PSD. |
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