| 王志明,赵嫦清,杨丽霞.细胞外基质金属蛋白酶诱导因子在动脉粥样硬化核因子 κB信号通路交叉调控中的研究进展[J].安徽医药,2020,24(1):65-68. |
| 细胞外基质金属蛋白酶诱导因子在动脉粥样硬化核因子 κB信号通路交叉调控中的研究进展 |
| Research progress of EMMPRIN in the cross regulation of NF?kappa B signaling pathway in atherosclerosis |
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| DOI：10.3969/j.issn.1009?6469.2020.01.017 |
| 中文关键词: 动脉粥样硬化 基质金属蛋白酶类，膜相关 NF?κB 信号传导 自噬 综述 促炎蛋白 |
| 英文关键词: Atherosclerosis Matrix metalloproteinases,membrane?associated NF?kappa B Signal transduction Autophagy Review Proinflammatory protein |
| 基金项目: |
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| 中文摘要: |
| 动脉粥样硬化( Atherosclerosis，AS)是心脑血管疾病发生、发展重要的病理基础。细胞外基质金属蛋白酶诱导因子(Extracellular Matrix Metalloproteinase Inducer，EMMPRIN)，作为一种广泛分布的、细胞表面糖基化的跨膜蛋白，是 AS重要的促炎蛋白。然而 EMMPRIN在 AS中的细胞信号通路众多且机制繁杂，现着重就 EMMPRIN围绕核因子 κB(Nuclear Factor κB， NF?κB)及其上下游信号通路交叉调控，诱导动脉粥样硬化形成的研究进展作一综述。 |
| 英文摘要: |
| Atherosclerosis(AS)is an important pathological basis for the occurrence and development of cardiovascular and cere?brovascular diseases.The extracellular matrix metalloproteinase inducer(EMMPRIN)，as a widely distributed，cell surface glycosyl? ated transmembrane protein，is an important proinflammatory protein of AS.However，the cell signaling pathway in AS is numerousand the mechanism is complex.It is focused on the progress of the research on the cross regulation of EMMPRIN around nuclearfactor kappa B(NF?kappa B)and its upstream and downstream signaling pathways to induce atherosclerosis. |
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