| 谢宇宽,李杨,陈艳琼,等.联合治疗方案对原发性失眠病人睡眠质量、抑郁情绪及睡眠结构指标的影响[J].安徽医药,2020,24(4):771-774. |
| 联合治疗方案对原发性失眠病人睡眠质量、抑郁情绪及睡眠结构指标的影响 |
| Influence of combined treatment scheme on sleep quality， depression and sleep structure index of patients with primary insomnia |
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| DOI：10.3969/j.issn.1009?6469.2020.04.034 |
| 中文关键词: 入睡和睡眠障碍 经颅磁刺激 唑吡坦 抑郁症 睡眠期 |
| 英文关键词: Sleep initiation and maintenance disorders Transcranial magnetic stimulation Zolpidem Depressive disorder Sleep stages |
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| 中文摘要: |
| 目的探讨联合治疗方案对原发性失眠病人睡眠质量、负面情绪及睡眠结构指标的影响。方法选取自贡市精神卫生中心 2016年 1月至 2018年 1月收治原发性失眠病人共 160例，以随机数字表法分为对照组( 80例)和观察组( 80例)，其中对照组给予唑吡坦 +经颅磁刺激( rTMS)假性刺激治疗，观察组给予唑吡坦 +rTMS真性刺激；比较两组病人近期疗效，治疗前后匹茨堡睡眠质量指数量表( PSQI)评分、简单自测抑郁量表( PHQ?9)评分、多导睡眠监测指标、睡眠结构指标水平及不良反应发生率。结果观察组病人近期治疗总有效率为 96.25%，明显优于对照组的 84.21%(P＜0.05)；对照组治疗后 1周、 4周及 8周 PSQI评分分别为( 10.92±2.31)分，(8.49±1.92)分，(7.77±1.38)分；观察组治疗后 1周、 4周及 8周 PSQI评分分别为( 9.38±2.09)分，(7.12±1.60)分，(5.49±1.01)分；对照组治疗后 1周、 4周及 8周 PHQ?9评分分别为( 5.96±1.02)分，(5.48±0.89)分，(5.08±0.71)分；观察组治疗后 1周、 4周及 8周 PHQ?9评分分别为( 5.17±0.89)分，(4.73±0.63)分，(3.84±0.40)分；观察组病人治疗后 PSQI评分、 PHQ?9评分、多导睡眠监测指标及睡眠结构指标水平均显著优于对照组、治疗前( P＜0.05)；同时两组病人不良反应发生率比较差异无统计学意义( P＞0.05)。结论联合治疗方案用于原发性失眠病人治疗可有效提高睡眠质量，减轻抑郁情绪，改善睡眠结构，且安全性值得认可。 |
| 英文摘要: |
| Objective To investigate the influence of combined treatment scheme on sleep quality，depression and sleep structure index of patients with primary insomnia.Methods A hundred and sixty patients with primary insomnia treated in Mental HealthCenter of Zigong City during the period from January 2016 to January 2018 were randomly assigned into control group(80 pa? tients) and observation group(80 patients) using random number table method.The control group was treated with zolpidem +sham repetitive transcranial magnetic stimulation(rTMS)and the observation group was treated with zolpidem + low?frequency rT?MS.Comparison was made between the two groups of the short?term clinical efficacy，preoperative and postoperative Pittsburgh sleep quality index(PSQI)scores，nine?item patient health questionnaire(PHQ?9)score，polysomnography index and sleep structure in? dex and the incidence of adverse reactions.Results The short?term clinical efficacy(96.25%)of the observation group was signifi? cantly higher than that of the control group(84.21%，P＜0.05).The PSQI scores of the control group at 1 week，4 weeks and 8 weeks after treatment were(10.92±2.31)points，(8.49±1.92)points，(7.77±1.38)points，respectively；the PSQI scores of the obser? vation group at 1 week，4 weeks and 8 weeks after treatment were(9.38±2.09)points，(7.12±1.60)points，(5.49±1.01)points，re? spectively.The PHQ?9 scores of the control group at 1 week，4 weeks and 8 weeks after treatment were(5.96±1.02)points，(5.48±0.89)points，(5.08±0.71)points，respectively；the PHQ?9 scores of the observation group at 1 week，4 weeks and 8 weeks after treatment were(5.17±0.89)points，(4.73±0.63)points，(3.84±0.40)points，respectively.The PSQI scores，PHQ?9 scores，polysom?nography index level and sleep structure index level of the observation group after treatmentwere significantly higher than those ofthe control group and those before treatment(P＜0.05).There was no significant difference in the incidence of adverse reactions be? tween two groups(P＞0.05).Conclusion Combined treatment scheme in the treatment of patients with primary insomnia can ef? fectively improve sleep quality，relieve depression，improve sleep structure，whose safety is worthy of recognition. |
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