| 刘清华,农加利.超早期针刺治疗重型颅脑损伤 35例[J].安徽医药,2020,24(5):920-923. |
| 超早期针刺治疗重型颅脑损伤 35例 |
| Treatment of severe craniocerebral injury with ultra?early acupuncture:35 case |
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| DOI：10.3969/j.issn.1009?6469.2020.05.018 |
| 中文关键词: 颅脑损伤 针刺穴位 白细胞介素 6 格拉斯哥昏迷量表 |
| 英文关键词: Craniocerebral trauma Acupuncture points Interleukin?6 Glasgow coma scale |
| 基金项目: |
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| 中文摘要: |
| 目的探讨超早期应用针刺治疗重型颅脑损伤的临床疗效及对病人脑脊液中白细胞介素 ?6(IL?6)含量的影响。方法选取 2016年 7月至 2019年 2月广西壮族自治区人民医院生命体征平稳的重型颅脑损伤病人 71例，采用随机数字表法分为对照组( 36例)及针刺组( 35例)对照组行常规西医治疗；针刺组在常规西医治疗基础上加用针刺治疗(于入院后第 1天开始)，治疗时间为 3周。治疗前及开始治，疗后第 1、3、7天时，使用酶联免疫吸附法( ELISA)测定两组病人脑脊液 IL?6水平，并比较两组病人治疗前后格拉斯哥昏迷评分( GCS)、苏醒率及催醒时间的差异。结果治疗前针刺组与对照组 IL?6水平差异无统计学意义［(3 596.4±1 906.8)比( 3 650.9±2 001.6)mg/L，P＞0.05)］，治疗后第 1，3，7天时，针刺组 IL?6水平［(1 694.5±739.1)、(250.6± 100.6)、(469.7±196.3)mg/L］明显低于对照组［(2 384.9±1 007.4)、(556.2±166.9)、(695.2±277.8)mg/L］均差异有统计学意义(P＜0.05)； GCS评分针刺组［(11.9±4.3)比( 5.6±1.8)分］与对照组［(10.2±4.1)比( 5.5±1.6)分］治疗后较治疗，前均明显改善( P＜0.05)；针刺组 GCS评分［(11.9±4.3)比( 10.2±4.1)分］及催醒所需时间［(6.8±2.9)比( 9.1±3.6)d］、苏醒率［80.0%比 60.0%］均优于对照组( P＜0.05)。结论超早期针刺治疗可有效降低颅脑损伤后病人脑脊液中 IL?6的含量，提高重型颅脑损伤病人的 GCS评分，促进重型颅脑损伤昏迷病人苏醒。 |
| 英文摘要: |
| Objective To investigate the clinical effect of acupuncture in the treatment of severe craniocerebral injury and the ef?fect on the Interleukin?6(IL?6)level in cerebrospinal fluid of patients with severe craniocerebral injury.Methods Sixty patientswith severe craniocerebral injury were randomly divided into the acupuncture group and the control group.The patients in the con?trol group were treated with routine western medicine and the patients in the acupuncture group were treated with acupuncture onthe basis of routine treatment(starting on the first day after admission)for 3 weeks.The levels of IL?6 in cerebrospinal fluid of the two groups were measured by enzyme linked immunosorbent assay(ELISA)before and on the 1st，3rd and 7th day after treatment. The glasgow coma score(GCS)，recovery rate and awakening time were compared between the two groups before and after the treat? ment.Results There was no significant difference in IL?6 level between the two groups before treatment［( 3 596.4±1 906.8)vs.(3 650.9±2 001.6)mg/L，P＞0.05］.However，on the 1st，3rd and 7th day after treatment，the level of IL?6 in the acupuncture group was significantly lower than that in the control group［( 1 694.5±739.1)(250.6±100.6)(469.7±196.3)mg/L］vs.［( 2 384.9± 1 007.4)，(556.2±166.9)，(695.2±277.8)mg/L］(P＜0.05).Comparedwitht，he control group，t，he GCS score［(11.9±4.3)vs.(10.2±4.1)cases］，awakening time［(6.8±2.9)vs.(9.1±3.6)d］and recovery rate［80.0% vs. 60.0%］in acupuncture group were better than those in the control group(P＜0.05).Conclusion Ultra?early acupuncture can effectively reduce the level of IL?6 in cerebrospi?nal fluid of patients with severe craniocerebral injury，increase the GCS score of patients with severe craniocerebral injury，and pro? mote the recovery of coma patients with severe craniocerebral injury. |
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