| 吴莲,何怡,曹平.大动脉粥样硬化型脑梗死急性期情感淡漠与血清甲状腺激素水平及卒中功能障碍的相关性[J].安徽医药,2020,24(5):931-934. |
| 大动脉粥样硬化型脑梗死急性期情感淡漠与血清甲状腺激素水平及卒中功能障碍的相关性 |
| Correlation of apathy during the acute stage of large artery atherosclerotic cerebral infarction with serum thyroid hormone level and functional disabifity |
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| DOI：10.3969/j.issn.1009?6469.2020.05.021 |
| 中文关键词: 脑梗死 情感淡漠 促甲状腺素 甲状腺原氨酸类 动脉粥样硬化 |
| 英文关键词: Cerebral infarction Apathy Thyrotropin Thyronines Atherosclerosis |
| 基金项目:重庆市璧山区科学技术委员会科技计划项目( 2017?16) |
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| 中文摘要: |
| 目的探讨大动脉粥样硬化型脑梗死( LAACI)急性期情感淡漠的发生率及与血浆甲状腺激素水平、卒中功能障碍的相关性。方法选取 2017年 3月至 2018年 9月重庆市璧山区人民医院 LAACI病人 188例为病例组，选取重庆市璧山区人民医院同期具有明确脑动脉粥样硬化危险因素的体检者 188例为对照组。使用修订版情感淡漠评定量表( MAES)分别进行情感淡漠评分，将 MAES评分＞ 14分定义为情感淡漠。根据 MAES评分将病例组分为情感淡漠组和非情感淡漠组。用 mRS评定卒中功能障碍，应用 BI评分评估日常生活能力，同时抽取静脉血检测血浆促甲状腺激素( TSH)、三碘甲状腺原氨酸( T3)、游离三碘甲状腺原氨酸( FT3)、四碘甲状腺原氨酸( T4)及游离四碘甲状腺原氨酸( FT4)。结果病例组淡漠发生率明显高于对照组(39.89%)比( 9.04%，χ2＝65.234，P＝0.001)。在病例组中，情感淡漠组年龄、 mRS评分、 TSH水平明显高于非情感淡漠组［年龄(67.84±10.32)比( 60.23±11.12)岁； mRS(2.89±1.12)比( 1.87±1.09)分； TSH(3.83±0.92)比( 2.23±0.67)mU/L，均 P＜0.05］。而情感淡漠组受教育年限、 BI评分、 T3、FT3水平明显低于非情感淡漠组［受教育年限( 4.31±2.13)比( 8.98±3.39)年； BI(71.81±13.39)比( 87.12±10.87)分； T3(1.46±0.85)比( 2.13±1.05)nmol/L；FT3(3.08±1.12)比( 4.98±1.04)pmol/L；均 P＜0.05］。在情感淡漠组中 mRS评分、 TSH水平与 MAES评分呈正相关(BmRS＝1.506，P＝0.002；BTSH＝0.165，P＝0.012)； T3及 FT3水平与 MAES评分呈负相关(BT3＝-0.856，P＝0.030；BFT3＝-0.801，P＝0.034)。结论 LAACI急性期情感淡漠与血浆 TSH、T3、FT3水平及卒中功能障碍相关。 |
| 英文摘要: |
| Objective To investigate the incidence and whether apathy during the acute stage of large artery atherosclerotic cere? bral infarction(LAACI)was related to thyroid hormone and functional disability.Methods Totally 188 patients with LAACI who met the inclusion criteria were recruited from the Department of Neurology，People’s Hospital of Bi’shan District.188 volunteers of the control group were recruited from medical center in our hospital during the same period.Apathy was assessed using modified ap?athy evaluation scale(MAES).According to the MAES score，LAACI patients were divided into the apathy group(MAES was more than 14 points)and the non?apathy group.Modified Rankin SeMe(mRS)was used to assess functional disability.Functional disabil? ity in daily living activities was assessed with the Barthel Index(BI).Serum levels of thyrotropine(TSH)，triiodothyronine(T3)，free triiodothyronine(FT3)，tetraiodothyronine(T4)and free tetraiodothyronine(FT4)of patients were determined.Results The preva? lence of apathy in patients was significantly higher than the control group(39.89% vs. 9.04%，χ2＝65.234，P＝0.001).In the case group，compared with the non?apathy group，the age，mRS score and plasma TSH level of apathy group were significantly increased［age(67.84±10.32 vs. 60.23±11.12)years，mRS scor(2.89±1.12 vs. 1.87±1.09)points，TSH(3.83±0.92 vs. 2.23±0.67)mU/L，all P＜0.05］.Compared with non?apathy group，the education level，BI score，plasma T3，FT3 level of apathy group were significantly lower［education level(4.31±2.13)vs.(8.98±3.39)years，BI(71.81±13.39 vs. 87.12±10.87)，T3(1.46±0.85 vs. 2.13±1.05)nmol/L，FT3(3.08±1.12 vs. 4.98±1.04)pmol/L，all P＜0.05］.In the apathy group，the mRS score and plasma TSH level were positively corre? lated with the MAES score(BmRS＝1.506，P＝0.002.BTSH＝0.165，P＝0.012)，serum T3，FT3 level were positively with the MAES score(BT3＝-0.856，P＝0.030.BFT3＝-0.801，P＝0.034).Conclusion The plasma TSH，T3，FT3 level and functional disability are closely related to apathy during the acute stage of LAACI. |
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