| 李园园,杜林哲.药物性肝损伤 184例病因分析[J].安徽医药,2020,24(7):1474-1476. |
| 药物性肝损伤 184例病因分析 |
| nalysis of 184 cases of drug?induced liver damage |
| |
| DOI：10.3969/j.issn.1009?6469.2020.07.051 |
| 中文关键词: 药物性肝损伤病因学 处方 药物疗法管理 中草药 镇痛药 退热药 药学监护 |
| 英文关键词: Drug?induced liver injury/etiology Prescriptions Medication therapy management Drugs,Chinese herbal Analgesics Antipyretics Pharmaceutical care |
| 基金项目: |
|
| 摘要点击次数: 1808 |
| 全文下载次数: 491 |
| 中文摘要: |
| 目的回顾分析南京医科大学附属南京医院(南京市第一医院)诊断为药物性肝损伤( DILI)病例，探讨药学监护和用药教育对 DILI的意义。方法对 2014年 3月至 2019年 3月南京医科大学附属南京医院(南京市第一医院) DILI病人的临床资料，包括一般情况、临床诊断、肝功能指标、既往用药史、临床症状体征、其他实验室检查，然后进行统计分析。结果 240例诊断 DILI的病人经因果关系评价表( RUCAM)量表筛选出 184例。病人年龄范围 18～85岁，年龄( 56.13±14.21)岁，住院天数(11.40±5.66)d。严重程度分布为轻度损伤 36例( 19.56%)，中度损伤 52例( 28.26%)重度损伤 89例( 48.37%)急性肝衰竭 7例(3.8%)。起病前涉及药物用药天数的中位数为 30 d。导致 DILI的药物中，中药 44成药 42例，降脂药2例，解热镇痛药 19例。结论导致 DILI最常见的药物是传统中药、中成药、降脂药物和解热镇痛药。应加强对 DILI的管理和预防，药师积极开展 DILI相关的用药监护和用药教育工作，以降低 DILI的发生。 |
| 英文摘要: |
| Objective Toretrospectively review and analyze the cases of drug⁃induced liver injury（DILI）in Nanjing Hospital Af⁃ filiated to Nanjing Medical University，and to probe the significance of pharmaceutical monitoring and medication education for DI⁃ LI.Methods Clinical data of DILI patients in our hospital from March 2014 to March 2019，including general conditions，clinical diagnosis，liver function indexes，previous medication history，clinical symptoms and signs，other laboratory tests，were collected and analysed.included Results A total of 184 cases were chosen from 240 cases of DILI by the Roussel Uclaf Causality Assessment Method（RUCAM）.The patient’s age ranged from 18 to 85 years，the age was（56.13±14.21）years，and the length of hospital stay was（11.40±5.66）days.The severity distribution was 36 cases（19.56%）with mild injury，52 cases（28.26%）with moderate inju⁃ ry，89 cases（48.37%）with severe injury，and 7 cases（3.8%）with acute liver failure.The median of intake duration of the in⁃ volved drugs was 30 days.Among the drugs causing DILI，44 were Chinese medicines，42 were Chinese patent medicines，22 were lipid⁃lowering drugs，and 19 were antipyretic and analgesic drugs.Conclusions The most common drugs that induce DILI are tra⁃ ditional Chinese medicine，Chinese patent medicine，anti⁃lipemic agents and antipyretic analgesics.The management and preventivemeasures of DILI should be strengthened.Pharmacists should pay attention to and actively carry out drug monitoring and medicationeducation about DILI to reduce the occurrence of DILI. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
