| 于梦尧,鲁春,冯李明,等.草酸艾司西酞普兰联合左甲状腺素钠治疗亚临床甲状腺功能减退伴焦虑抑郁 30例[J].安徽医药,2020,24(8):1655-1658. |
| 草酸艾司西酞普兰联合左甲状腺素钠治疗亚临床甲状腺功能减退伴焦虑抑郁 30例 |
| Effects of escitalopram oxalate and levothyroxine sodium treatment on patients of subclinical hypothyroidism combined with anxiety and depression:an analysis of 30 cases |
| |
| DOI：10.3969/j.issn.1009?6469.2020.08.046 |
| 中文关键词: 甲状腺功能减退/药物疗法 西酞普兰 左甲状腺素钠 焦虑 抑郁 |
| 英文关键词: Hypothyroidism/drug therapy Citalopram Levothyroxine sodium Anxiety Depression |
| 基金项目: |
|
| 摘要点击次数: 2023 |
| 全文下载次数: 646 |
| 中文摘要: |
| 目的观察草酸艾司西酞普兰联合左甲状腺素钠治疗亚临床甲状腺功能减退伴焦虑抑郁的效果。方法选取 2015年 1月至 2018年 7月东海县人民医院亚临床甲状腺功能减退伴焦虑抑郁病人 90例，采用随机数字表法分为西酞普兰组、左甲状腺素钠组和联合组，每组 30例。分别予以草酸艾司西酞普兰、左甲状腺素钠和草酸艾司西酞普兰 +左甲状腺素钠联合治疗。 8周后，观察三组治疗前后游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平和汉密尔顿焦虑量表(HAMA)及汉密尔顿抑郁量表(HAMD)评分的变化。结果治疗后与治疗前相比，西酞普兰组 TSH［(7.70±1.09)μIU/mL比(7.77±1.03)μIU/mL］、 FT3［(4.28±0.73)pmol/L比(4.30±0.58)pmol/L］、 FT4［(9.72±1.03)pmol/L比(9.98±1.09)pmol/L］无变化(P＞0.05)TSH左甲状腺素钠组［(4.39±0.76)μIU/mL比(7.69±1.01)μIU/mL］和联合组［(4.30±0.51)μIU/mL比(7.78±0.98)μIU/ mL］下降，F，T3左甲状腺素钠组［(5.85±0.81)pmol/L比(4.34±0.67)pmol/L］和联合组［(5.63±0.54)pmol/L比(4.27±0.63)pmol/L］升高、 FT4左甲状腺素钠组［(13.22±1.56)pmol/L比(10.22±1.30)pmol/L］和联合组［(12.69±1.31)pmol/L比(9.89±1.12)pmol/L］升高(P＜0.05)。治疗后 HAMA和 HAMD评分与治疗前相比，西酞普兰组［(12.60±1.35)分比(21.90±2.56)分］、［(12.57±1.61)分比(22.16±1.72)分］左甲状腺素钠组［(14.50±1.54)分比(21.30±2.39)分］、［(13.90±2.64)分比(22.93±1.85)分］和联合组［(8.36±1.73)分比(20.4，3±3.08)分］、［(8.26±1.63)分比(21.96±1.62)分］下降(P＜0.05)。与西酞普兰组、左甲状腺素钠组相比，联合组 HAMA和 HAMD评分下降(P＜0.05)。结论草酸艾司西酞普兰或左甲状腺素钠均可以缓解亚临床甲状腺功能减退伴焦虑抑郁病人的焦虑抑郁症状，联合用药疗效优于单药治疗。 |
| 英文摘要: |
| Objective To observe the efficacy of escitalopram oxalate and levothyroxine sodium on the treatment of patients withsubclinical hypothyroidism combined with anxiety and depression.Methods Ninety patients of subclinical hypothyroidism com? bined with anxiety and depression，who were treated in Donghai People’s Hospital from January 2015 to July 2018，were chosen and randomly assigned into escitalopram group(n＝30)，levothyroxine group(n＝30)and combined group(n＝30).The patients were treated with escitalopram oxalate，levothyroxine sodium，and escitalopram oxalate plus levoth yroxine sodium，respectively.After 8 weeks，thyroid stimulating hormone(TSH)free triiodothyronine(FT3)，and free tetraiodothyronine(FT4)levels before and after thetreatmen tweretested and HamiltonAnxiety，Rating Scale(HAMA)and Hamilton Depression Rating Scale(HAMD)were used to evaluate the emotional status.Results In comparison with pretreatment，the TSH［(7.70±1.09)μIU/mL vs.(7.77±1.03)μIU/ mL］FT3［(4.28±0.73)pmol/L vs.(4.30±0.58)pmol/L］，FT4 levels［(9.72±1.03)pmol/L vs.(9.98±1.09)pmol/L］of escitalopram groupw，ere unchanged after treatment(P＞0.05).TSH levels were decreased in levothyroxine group［(4.39±0.76)μIU/mL vs.(7.69±1.01)μIU/mL］and combined group［(4.30±0.51)μIU/mL vs.(7.78±0.98)μIU/mL］(P＜0.05)and FT3 levels were in? creased in levothyroxine group［(5.85±0.81)pmol/L vs.(4.34±0.67)pmol/L］and combined group［(5.63±0.54)pmol/L vs.(4.27±0.63)pmol/L］(P＜0.05).FT4 levels were increased in levothyroxine group［(13.22±1.56)pmol/L vs.(10.22±1.30)pmol/L］and combined group［(12.69±1.31)pmol/L vs.(9.89±1.12)pmol/L］(P＜0.05).In comparison with pretreatment，the HAMA and HAMD scores were decreased in escitalopram group［(12.60±1.35)vs.(21.90±2.56)］，［(12.57±1.61)vs.(22.16±1.72)］levothyroxine group［(14.50±1.54)vs.(21.30±2.39)］，［(13.90±2.64)vs.(22.93±1.85)］and combined group［(8.36±1.73)vs.(203±3.08)］［(8.26±1.63)vs.(21.96±1.62)］ after treatment(P＜0.05).In comparison with escitalopram group and levothyroxine group，the HAMA and HAMD scores were decreased in combined group(P＜0.05).Conclusion Escitalopram oxalate plus levothyroxine so?dium could alleviate the symptoms of anxiety and depression of patients with subclinical hypothyroidism.Combined treatment wasmore effective than monotherapy. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
