| 杨亚文,林小满,孙礼强,等.子痫前期病人血清相关炎性因子及胎盘生长因子的变化及意义[J].安徽医药,2020,24(9):1776-1778. |
| 子痫前期病人血清相关炎性因子及胎盘生长因子的变化及意义 |
| Changes and significance of serum inflammatory factors and placental growth factors in patients with preeclampsia |
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| DOI：10.3969/j.issn.1009-6469.2020.09.020 |
| 中文关键词: 子痫前期 炎性因子 白细胞介素 4 白细胞介素 12 胎盘生长因子 |
| 英文关键词: Pre-eclampsia Inflammatoryfactor Interleukin 4 Interleukin 12 Placental growth factor |
| 基金项目:徐州市重点研发计划(社会发展)项目( KC18214) |
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| 中文摘要: |
| 目的探讨子痫前期病人血清中白细胞介素 12(IL-12)白细胞介素 4(IL-4)及胎盘生长因子( PLGF)水平与子痫前期发病的关系。方法选择 2019年 1—5月在徐州医科大学附属医院，产科收治并分娩的子痫前期孕妇 70例，其中早发型子痫前期组 33例，晚发型子痫前期组 37例，同期住院分娩的正常妊娠孕妇 30例为对照组。采用酶联免疫吸附试验( ELISA)测定各组孕妇血清中 IL-12，IL-4，PLGF含量。采用 xˉ± s、单因素方差分析等进行统计学分析。结果早发型子痫前期组血清 PLGF含量(270.34±37.69)pg/mL低于晚发型子痫前期组( 305.32±37.77)pg/mL，两组均低于对照组( 365.76±18.94)pg/mL(P＜0.05)；早发型子痫前期组血清 IL-12含量( 179.36±12.93)pg/mL高于晚发型子痫前期组( 158.11±20.55)pg/mL，两组均高于对照组( 131.51±8.88)pg/mL(P＜0.05)；早发型子痫前期组及晚发型子痫前期组 IL-4含量( 28.82±3.76)pg/mL及( 31.36±4.01)pg/mL均低于对照组( 35.36±3.52)pg/mL(P＜0.05)早发组与晚发组差异无统计学意义( P＞0.05)。结论孕妇血清中 PLGF及 IL-4随着子痫前期病情进展降低， IL-12随着子期病情进展升高，提示免疫失衡可能影响胎盘功能，加剧子痫前期的病情进展。痫前， |
| 英文摘要: |
| Objective To investigate the relationship between interleukin-12(IL-12)，interleukin-4(IL-4)and placental growth fac- tor(PLGF)levels and the onset of preeclampsia in patients with preeclampsia.Methods Seventy cases of pregnant women withpreeclampsia admitted and delivered in obstetrics department of The Affiliated Hospital of Xuzhou Medical University from January2019 to May 2019 were selected，including 33 cases in the early-onset preeclampsia group and 37 cases in the late-onset pre-eclampsia group.Thirty cases of normal pregnant women hospitalized for delivery during the same period were selected as the con-trol group.Serum levels of IL-12，IL-4 and PLGF were determined by ELISA.The mean ± standard deviation and one-way anova were used for statistical analysis.Results Serum PLGF content in early-onset preeclampsia group(270.34±37.69)pg/mL was low- er than that in late-onset preeclampsia group(305.32±37.77)pg/mL，and both groups were lower than the control group(365.76±18.94)pg/mL(P＜0.05).Serum IL-12 content in early-onset preeclampsia group(179.36±12.93)pg/mL was higher than that in late-onset preeclampsia group(158.11±20.55)pg/mL，and both groups were higher than the control group(131.51±8.88)pg/mL(P＜0.05).The IL-4 content in early-onset preeclampsia group(28.82±3.76)pg/mL and late-onset preeclampsia group(31.36±4.01)pg/mL were lower than that in the control group(P＜0.05)，the early onset group was lower than the late onset group，but the difference was not statistically significant.Conclusion Serum levels of PLGF and IL-4 in pregnant women decreased while IL- 12 increased with the progression of preeclampsia，which suggests that immune imblance may affect placental function and aggra- vate the progress of preeclampsia. |
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