| 付哲祥,李昌松.胸部孤立性纤维性肿瘤多层螺旋CT表现及与人表皮生长因子受体2表达的相关性[J].安徽医药,2020,24(9):1811-1815. |
| 胸部孤立性纤维性肿瘤多层螺旋CT表现及与人表皮生长因子受体2表达的相关性 |
| Multisliecs helieal CT manifestations of solitary fibrous tumors of the chest and their correlations with the expression of human epidermal growth factor receptor 2 |
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| DOI：10.3969/j.issn.1009-6469.2020.09.029 |
| 中文关键词: 胸部肿瘤 /诊断 间质细胞 受体，表皮生长因子 多探头的计算机断层扫描 孤立性纤维性肿瘤 最大强化率 |
| 英文关键词: Thoracic neoplasms/diagnosis Stromal cells Receptor,epidermal growth factor Multidetector computed tomogra-phy Solitary fibrous tumor Maximum strengthening rate |
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| 中文摘要: |
| 目的探讨胸部孤立性纤维性肿瘤( SFT)多层螺旋 CT(MSCT)表现及与肿瘤组织人表皮生长因子受体 2(CerbB-2)蛋白表达的相关性。方法回顾性分析汉川市人民医院 2010年 10月至 2018年 10月经手术和病理证实的 25例 SFT病人临床资料。 MSCT扫描观察胸部 SFT部位、形态、密度及与周围组织关系等，并采用免疫组织化学 SP法检测肿瘤组织中 CerbB-2蛋白表达，分析 MSCT影像指标与 CerbB-2蛋白表达关系。结果肿瘤形态多呈不规则形或圆形，仅有 2例呈浅分叶状； 22例边缘清晰， 3例边缘不清； 6例病人肿瘤密度 CT平扫较均匀， CT增强扫描呈强化均匀； 19例病人肿瘤密度 CT平扫不均匀，可见坏死及不规则钙化，且 CT增强扫描呈强化不均匀，其中 7例动脉期呈轻、中度不均匀强化； 4例强化呈条状钙化或斑片状， 9例可见增强血管影；且肿瘤最大直径( 12.01±4.97)cm，肿瘤实质平扫 CT值( 35.72±9.13)HU，肿瘤实质增强 CT值( 67.48±20.52)HU，静脉期最大强化率( vCER)(154.32±48.70)%。胸部 SFT病人组织中 CerbB-2蛋白阴性 10例、弱阳性 7例、中阳性 5例、强阳性 3例，阳性率为 60.00%。胸部 SFT病人肿瘤最大直径、肿瘤实质平扫 CT值、肿瘤实质增强 CT值及静脉期 vCER均与 CerbB-2蛋白表达呈正相关( P＜0.05)。肿瘤实质血管数、 CerbB-2蛋白表达均是胸部 SFT病人静脉期 vCER的影响因素( P＜0.05)。结论胸部 SFT的 MSCT表现多呈边缘清晰和进行性不均匀强化，且 MSCT影像学指标与肿瘤组织 CerbB-2蛋白表达呈正相关，可为临床治疗提供一定依据。 |
| 英文摘要: |
| Objective To investigate the multi-slice spiral CT(MSCT)manifestations of solitary fibrous tumors(SFT)of the chest and their correlations with the expression of human epidermal growth factor receptor 2(CerbB-2)protein.Methods The clinical data of 25 patients with thoracic SFT confirmed by surgery and pathology from October 2010 to October 2018 in Hanchuan People’ s Hospital were retrospectively analyzed.MSCT scans were performed to observe the location，morphology，density of SFT and its re-lationship with surrounding tissues.The expression of CerbB-2 protein in tumor tissues was detected by immunohistochemical SPmethod，and the relationships between MSCT imaging parameters with the expression of SerbB-2 protein were analyzed.Results Most of the tumors were irregular or round in shape，and only 2 of them were superficially lobulated；22 cases had clear margins and 3 cases had unclear margins；tumor density of CT scan in 6 patients was uneven，and CT enhanced scan showed even enhance- ment；in 19 cases，the tumor density of CT scan was uneven，necrosis and irregular calcification were observed，and CT enhanced scan showed uneven enhancement，of which 7 cases showed mild or moderate uneven enhancement in arterial phase；four cases showed strip calcification or patchy enhancement，and 9 cases showed enhanced vascular shadow；the mean maximum diameter of tumors was(12.01±4.97)cm，the mean plain-scan CT value of tumor parenchyma was(35.72±9.13)HU，the mean enhanced CT value of tumor parenchyma was(67.48±20.52)HU，and the mean venous phase contrast enhancement ratio(vCER)was(154.32±48.70)%.CerbB-2 protein of thoracic SFT was negative in 10 cases，weakly positive in 7 cases，moderately positive in 5 cases，and strongly positive in 3 cases，the positive rate was 60.00%.The mean maximum diameter of tumors，the mean plain-scan CT value of tumor parenchyma，the mean enhanced CT value of tumor parenchyma，and the vCER in patients with thoracic SFT were all posi- tively correlated with the expression of SerbB-2 protein(P＜0.05).Tumor parenchymal vessel number and cerbB-2 protein expres-sion were the influencing factors of vCER in venous phase of thoracic SFT patients(P＜0.05).Conclusion MSCT of thoracic SFT shows clear margins and progressive heterogeneous enhancement，and the imaging parameters of MSCT are positively correlated with the expression of CerbB-2 protein in tumor tissues，which can provide certain basis for clinical treatment. |
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