| 虎维东,张静,王小军,等.甲型 H1N1流感 73例 T淋巴细胞亚群分析[J].安徽医药,2020,24(10):1989-1991. |
| 甲型 H1N1流感 73例 T淋巴细胞亚群分析 |
| T cell immunity analysis in patients with influenza A virus subtype H1N1 |
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| DOI：10.3969/j.issn.1009?6469.2020.10.018 |
| 中文关键词: 流感，人 流感病毒 A型， H1N1亚型 CD4阳性 T淋巴细胞 CD8阳性 T淋巴细胞 T淋巴细胞亚群 |
| 英文关键词: Influenza,human Influenza A virus,H1N1 subtype CD4?positive T?lymphocytes CD8?positive T?lymphocytes Tcell immunity |
| 基金项目:甘肃省科技支撑社会发展类项目(1011FKCA100) |
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| 中文摘要: |
| 目的检测甲型 H1N1流感病人外周血 T淋巴细胞亚群的变化，探讨甲型 H1N1流感对其细胞免疫功能的影响。方法总结 2009年 11月 5日至 2017年 1月 15日甘肃省人民医院及兰州大学第二医院所收治的 73例临床资料完整且没有基础免疫疾病的甲型 H1N1流感病人血清总 T淋巴细胞、 CD4抗原阳性的 T淋巴细胞(CD4+T淋巴细胞)、 CD8抗原阳性的 T淋巴细胞(CD8+T淋巴细胞)活性的变化规律。结果甲型 H1N1流感病人 CD8+T淋巴细胞在诊断初期即已升高(42.27±11.13)cells/ul，并在恢复期基本恢复正常(29.26±12.99)cells/ul；总 T淋巴细胞、 CD4+T淋巴细胞则在诊断初期有不同程度下降(44.09±13.51)、(47.27±7.73)cells/ul，并随病情好转逐渐恢复， CD4+T淋巴细胞与 CD8+T淋巴细胞比值在病程中没有统计学差异差异无统计学意义(F=0.294，0.415，0.618；P=0.892，0.106，0.082)，但随病情好转有升高趋势。结论甲型 H1N1流感病人免疫功能低下。 |
| 英文摘要: |
| Objective To probe into the possible impact on T cell immunity in patients with A H1N1 influenza.Methods The changes of CD4 antigen positive T lymphocytes(CD4+ T cells)，CD8 antigen positive T lymphocytes(CD8+ T cells)and CD4+/CD8+ in 73 patients with A H1N1 influenza with complete clinical data and no underlying immune diseases were analyzed.From Novem?ber 5, 2009 to January 15, 2017, the patients in Gansu Provincial People's Hospital and the Second Hospital of Lanzhou University were treated.Results CD8+ T lymphocytes in patients with influenza A(H1N1)increased at the early stage of diagnosis(42.27±11.13 cells/uL)，and returned to normal in the recovery period(29.26±12.99 cells/uL)； the total T lymphocytes and CD4+ T lym?phocytes decreased to varying degrees(44.09±13.51 cells/uL，47.27±7.73 cells/uL，respectively)and gradually recovered with the improvement of the disease.There was no significant difference between the two groups(F=0.294.415，0.618；P=0.892，0.106，0，0.082)but it increased with the improvement of the disease.Conclusion T cell immunity are impaired in patients with a H1N1 influenza. |
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