| 史广林,马珺,严伟,等.外周血中性粒细胞和淋巴细胞计数比值、血小板平均体积与支气管哮喘的相关性研究[J].安徽医药,2020,24(12):2407-2410. |
| 外周血中性粒细胞和淋巴细胞计数比值、血小板平均体积与支气管哮喘的相关性研究 |
| Correlation between NLR，MPV in peripheral blood and bronchial asthma |
| |
| DOI：10.3969/j.issn.1009?6469.2020.12.019 |
| 中文关键词: 哮喘 中性粒细胞 /淋巴细胞计数比值 血小板平均体积 C反应蛋白质 降钙素 相关性 |
| 英文关键词: Asthma Neutrophil?lymphocyte ratio Mean platelet volume C?reactive protein Calcitonin Correlation |
| 基金项目:南通市卫生和计划生育委员会科研课题计划资助项目(WKZL2018072)；南通市市级科技计划(指导性)项目(JCZ18109) |
|
| 摘要点击次数: 1545 |
| 全文下载次数: 613 |
| 中文摘要: |
| 目的探讨中性粒细胞和淋巴细胞计数比值(NLR)及血小板平均体积(MPV)与支气管哮喘病情严重程度的相关性。方法选取 2017年 1月至 2018年 12月在南通市第六人民医院确诊的支气管哮喘病人共 162例，按照病情轻重分为稳定组、轻度组、重度组。记录不同组别的性别、年龄等资料及血常规、 C反应蛋白(CRP)、降钙素原(PCT)、最大呼气流量占正常预计值的百分比(PEF％)、哮喘控制测试(ACT)评分。比较三组间 MPV、NLR的差异，以及与炎症相关标志物、哮喘控制指标的相关性。结果除 PCT值在轻度组与稳定组间差异无统计学意义(P＞0.05)随着病人病情加重 NLR、MPV、PCT、CRP值重度组高于轻度组及稳定组，轻度组高于稳定组(均 P＜0.001)。 ACT评分、 PEF%值，重度组低于轻度组及稳定组，轻度组又低于稳定组(均 P＜0.001)。 NLR与 CRP、PCT(r＝0.430、0.334，P＝0.013、0.021)呈正相关； MPV与 CRP、PCT呈正相关(r＝0.243、0.370，P＝0.009、0.011)。NLR与CAT评分、 PEF%呈负相关(r＝-0.43、-0.37，P＝0.020、0.019)，MPV与CAT评分、 PEF%呈负相关(r＝-0.38、 -0.29，P＝0.014、0.030)。结论 NLR与 MPV与气管的炎性水平呈正相关、跟临床症状的指标呈负相关，能够在一定程度上反映病情严重程度，有利于哮喘病人的病情评估。 |
| 英文摘要: |
| Objective To investigate the correlation between neutrophil?lymphocyte ratio(NLR)and mean platelet volume(MPV) and the severity ofbronchial asthma.Methods Totally 162 patients with bronchial asthma diagnosed in The SixthPeople’sHospital? of Nantong from January 2017 to December 2018 were assigned into stable group，mild group and severe group according to the se? verity of the disease.The data of sex，age and blood routine，Creactive protein(CRP)，procalcitonin(PCT)，Interleukin?8(IL?8)，In? terleukin?6(IL?6)，peak expiratory flow(PEF%)and asthma control test(ACT)scores were recorded.The differences in MPV and NLR among the three groups were compared，and the correlation of MPV and NLR with inflammatory markers and asthma control indicators was studied.Results Except that no difference was found in PCT value between mild group and stable group(P＞0.05)，NLR，MPV，PCT and CRP values in severe group were higher than those in mild group and stable group，while the values in mild group were higher than those in stable group(all P＜0.001).ACT scores and PEF% in severe group were lower than those in mild group and stable group，while the values in mild group were lower than those in stable group(all P＜0.001).NLR was posi? tively correlated with CRP and PCT(r＝0.430，0.334，P＝0.013，0.021).MPVwas positively correlated with CRP and PCT(r＝0.243，0.370，P＝0.009，0.011).NLR was negatively correlated with CAT score and PEF%(r＝-0.43，-0.37，P＝0.020，0.019)and MPV was negatively correlated with CAT score and PEF%(r＝-0.38，-0.29，P＝0.014，0.030).Conclusion NLR and MPV are positively correlated with the inflammatory level of trachea and negatively correlated with the clinical symptoms，which can reflect the severity of the disease to a certain extent，and is conducive to the assessment of asthma patients. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
