| 冉启志,冉文,谭月,等.初诊鼻咽癌病人抑郁状态的相关因素研究[J].安徽医药,2021,25(1):40-43. |
| 初诊鼻咽癌病人抑郁状态的相关因素研究 |
| Related factors of depression in newly diagnosed nasopharyngeal carcinoma patients |
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| DOI：10.3969/j.issn.1009?6469.2021.01.010. |
| 中文关键词: 鼻咽肿瘤 抑郁 危险因素 C反应蛋白 |
| 英文关键词: Nasopharyngeal neoplasms Depression Risk factors C?reactive protein |
| 基金项目:成都中医药大学“杏林学者”学科人才提升计划医院专项(2018yky13)；四川省科技支撑计划(2015SZ0157) |
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| 中文摘要: |
| 目的探讨初诊鼻咽癌病人抑郁状态的发生率及危险因素。方法收集 2016年 1月至 2017年 12月四川大学华西医院收治的 122例鼻咽癌病人的临床资料，并对病人的性别、年龄、肿瘤分期(cTNM分期)、吸烟史、饮酒史、医疗费用来源、文化程度、癌性疼痛、睡眠状态、血清 C反应蛋白(CRP)水平等可能影响其发生抑郁状态的相关因素进行单因素和多因素分析。结果 122例初诊鼻咽癌病人中，有 32例出现抑郁状态，抑郁状态的发生率为 26.2％(32/122)其中男性 17例，女性 15例；单因素分析显示，病人年龄、性别、吸烟、疼痛、失眠及血清 CRP水平升高与抑郁状态有关(P＜0.05)，，多因素分析显示，鼻咽癌抑郁状态独立危险因素是年龄、吸烟、失眠、血清 CRP水平升高(P＜0.001)。结论初诊鼻咽癌病人抑郁状态的发生率较高。病人年龄、失眠、吸烟及 CRP与初诊鼻咽癌病人抑郁状态独立危险因素。 |
| 英文摘要: |
| Objective To investigate the incidence and related factors of depression in newly diagnosed nasopharyngeal carcino? ma(NPC).Methods The clinical data of 122 patients with NPC at West China Hospital of Sichuan University from January 2016to December 2017 were collected，and the univariate and multivariate logistic regression analysis were carried out on the related factors of depression，such as gender，patient’s age，the cTNM staging，smoking history，drinking history，medical expense source，ed? ucation，cancer pain，sleep state and serum CRP level.Results Of the 122 newly diagnosed NPC patients，32 cases had depres? sion，and the incidence of depression was 26.2%(32/122)including 17 males and 15 females.Univariate analysis showed that de? pression was associated with patient’s age，gender，smoking，p，ain，insomnia and high serum CRP expression(P＜0.05)，multivari? ate logistic regression analysis showed that patient’s age，smoking，insomnia and high serum CRP expression were independent risk factors for depression(P＜0.001).Conclusions The incidence of depression is higher in newly diagnosed nasopharyngeal carcino? ma patients.Patient’s age，insomnia，smoking and high serum CRP expression are independent risk factors for depression in newlydiagnosed NPC patients.It is necessary to strengthen the psychological evaluation and counseling for newly diagnosed NPC patients， and to strengthen the observation of the high?risk patients with insomnia，high serum CRP expression and smoking history，and to provide continuous and standardized psychosocial support to improve the psychological bearing capacity of patients. |
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