| 王宝勇,王银歌.老年性黄斑变性的性别相关性全球疾病负担[J].安徽医药,2021,25(1):184-187. |
| 老年性黄斑变性的性别相关性全球疾病负担 |
| Gender?related global disease burden in age?related macular degeneration |
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| DOI：10.3969/j.issn.1009?6469.2021.01.046 |
| 中文关键词: 黄斑变性 生命统计 公共卫生管理 伤残调整生命年 疾病负担 |
| 英文关键词: Macular degeneration Vital statistics Public health Administration Disability?adjusted life years Disease burden |
| 基金项目: |
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| 中文摘要: |
| 目的利用伤残调整生命年(disability?adjusted life yearDALY，DALY)探索性别与老年性黄斑变性(senile macular degeneration，SMD)全球疾病负担的关系及其对公共卫生政策的意义。方法通过进行一项国际性数据库观察研究，从全球健康数据交换(data exchange)数据库发表的 “2018年全球疾病负担研究”中提取了 1990年至 2017年全球性别特定性 SMD的疾病负担数值、粗略的疾病负担率和年龄标准化的疾病负担率，从而分析比较社会经济相关的性别差异对 SMD疾病负担的影响。结果 SMD引起的所有年龄段性别特异性全球疾病负担—伤残调整生命年数和伤残调整生命年率从 1990—2017年处于上升趋势，其中女性的伤残调整生命年数由 1990年的 151 958.39(95%UI:208 911.03～102 688.65)增加到 2017年的 307 576.72(95%UI:421 655.58～209 694.25)男性的从 1990年的 102 999.44(95%UI:142 727.58～69 913.40)到 2017年的 223 157.46(306 692.81～153 280.42)；女性的伤，残调整生命年率为 1990年 5.68(95%UI:7.80～3.84)至 2017年 8.08(95%UI:11.08～5.51)男性为 1990年 3.79(95%UI:5.25～2.57)至 2017年 5.82(95%UI:8.00～4.00)；女性年龄标准化的伤残调整生命年率从 19907.28(95%UI:10.00～4.92)下降到 2017年 7.16(95%UI:9.81～4.88)然而男性 SMD的年龄标准化的伤残调整生命年率从 1990年 6.13(95%UI:8.47～4.15)到 2000年出现短暂波动后，年升高到 6.26(95%UI:8.64～4.31)。曼—惠特年的，最终在2017，尼检验显示，三者均呈现性别差异(P＜0.01)。结论在过去的 28年中， SMD导致的疾病负担总体处于上升趋势，女性的疾病负担比男性更大。本研究的发现有助于提高公共卫生部门对 SMD全球疾病负担的关注，制定更优化的政策应对 SMD的治疗。 |
| 英文摘要: |
| Objective To explore the relationship between gender and the global burden of Senile macular degeneration(SMD) by using Disability Adjusted Life Years(DALY)and its implications for public health policy.Methods An international database observation study was conducted to extract the global gender?specific SMD burden values，rough disease burden rates and age?stan? dardized disease burden rates from 1990 to 2017 from t“2018 Global Burden of Disease Study”published by the Global Health Da? ta Exchange database，and to analyze and compare the impact of socioeconomic related gender differences on SMD disease burden. Results The gender?specific global burden of disease，DALY and its rate in all age groups caused by age?related macular degenera? tion，were on the rise from 1990 to 2017.Among them，the disability?adjusted life years for women increased from 151 958.39 in 1990(95%UI:208 911.03?102 688.65) to 2017.In 2010，307 576.72(95%UI:421 655.58?209 694.25) of males were from 102 999.44(95%UI:142 727.58?69 913.40)in 1990 to 223 157.46(306 692.81?153 280.42)in 2017，and the disability?adjusted life?year rate of females was from 5.68(95%UI:7.80?3.84)in 1990 to 8.08(95%UI:11.08?5.51)in 2017.From 3.79(95%UI:5.25?2.57)in 1990 to 5.82(95%UI:8.00?4.00)in 2017，the age?standardized disability?adjusted life?span rate for women decreased from 7.28(95%UI:10.00?4.92)in 1990 to 7.16(95%UI:9.81?4.88)in 2017.However，age?standardized disability?adjusted life? span rate for men with age?related macular degeneration was 7.16(95%UI:9.81?4.88).From 6.13 in 1990(95%UI:8.47?4.15)to 2000，after a short fluctuation，it finally rose to 6.26(95%UI:8.64?4.31)in 2017.Mann?Whitney test showed that there were signifi? cant gender differences among the three groups(P＜0.01).Conclusions In the past 28 years，the disease burden caused by age? related SMD has been on the rise in general，and the disease burden of women is greater than that of men.The findings of thisstudy will help to raise public health departments attention to the global burden of disease in age?related SMD and formulate moreoptimized policies to deal with the treatment of SMD. |
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