| 潘庆登,叶祖兰,曾春,等.非肾病性特发性膜性肾病与非肾病性 IgA肾病的临床特点比较[J].安徽医药,2021,25(2):268-270. |
| 非肾病性特发性膜性肾病与非肾病性 IgA肾病的临床特点比较 |
| Clinical comparative analysis of non-nephrotic idiopathic membranous nephropathy and non-nephrotic IgA nephropathy |
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| DOI：10.3969/j.issn.1009-6469.2021.02.014. |
| 中文关键词: 肾小球肾炎，膜性 肾小球肾炎， IGA 非肾病性特发性膜性肾病 非肾病性 IgA肾病 尿蛋白 血脂 肾功能异常 .68， |
| 英文关键词: Glomerulonephritis, membranous Glomerulonephritis, IGA Non-nephrotic idiopathic membranous nephropathy Non-nephrotic IgA nephropathy Urinary protein Dyslipidemia Renal dysfunction |
| 基金项目:北海巿科学研究与技术开发项目(北科合 201777033) |
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| 中文摘要: |
| 目的探讨非肾病性特发性膜性肾病( NSPN-IMN)与非肾病性 IgA肾病( NSPN-IgAN)的临床特点。方法选择 2013年 6月至 2018年 5月在北海市第二人民医院及医联体单位治疗的肾病病人 174例，其中 93例为 NSPN-IMN(NSPN-IMN组)，81例为 NSPN-IgAN(NSPN-IgAN组)，两组常规检测 24 h尿蛋白、血清白蛋白、血尿酸、总胆固醇( TC)、低密度脂蛋白( LDL)、三酰甘油( TG)和高密度脂蛋白( HDL)。比较两组各项临床指标。结果 NSPN-IMN组与 NSPN-IgAN组高血压发病率( 24.73%比38.27%)及性别分布( 50.54%比 44.44%)差异无统计学意义(均 P > 0.05)。 NSPN-IMN组年龄 > 50岁的比例高于 NSPN-IgAN组( 39.78%比 9.88%，P < 0.01)而肾功能异常的发病率低于 NSPN-IgAN组( 4.30%比 22.22%，P < 0.01)。 NSPN-IMN组的年龄［( 47.31±13.85)岁比( 35.28±12)岁］、尿蛋白［(2.12±0.87)g/24 h比( 1.18±0.84)g/24 h］、 TC［(7.29±2.16)mmol/L比( 5.04±0.92) mmol/L］、 HDL［(1.82±0.63)mmol/L比( 1.48±0.36)mmol/L］和 LDL［(4.86±1.88)mmol/L比( 3.31±0.68)mmol/L］均高于 NSPN-IgAN组(均 P < 0.01)，而血白蛋白低于 NSPN-IgAN组［( 28.64±7.09)g/L比( 40.36±6.58)g/L，P < 0.01］。两组尿酸［( 376.23±122.14) μmol/L比( 364.70±127.41)μmol/L］和 TG［( 1.90±1.18)mmol/L比( 1.61±1.18)mmol/L］差异无统计学意义( P > 0.05)。结论 NSPN-IMN组病人的年龄、尿蛋白、 TC、HDL和 LDL均高于 NSPN-IgAN组病人，而血白蛋白低于 NSPN-IgAN组。两组的高血压发病率及性别分布无明显差异。 NSPN-IgAN组肾功能异常的发病率高于 NSPN-IMN组。 |
| 英文摘要: |
| Objective To investigate the clinical characteristics of non-nephrotic syndromes proteinuria Idiopathic membranous nephropathy (NSPN-IMN) and non-nephrotic syndrome proteinuria IgA nephropathy (NSPN-IgAN).Methods A total of 174 nephrotic patients(93 cases of NSPN-IMN group and 81 cases of NSPN-IgAN group) treated in the Second People's Hospital of Beihai and co-operative hospital from June 2013 to May 2018,were selected as subjects of study.24-hour urinary protein,Serum albumin,total cholesterol(TC),low density cholesterol (LDL),triglyceride (TG) and high density cholesterol (HDL) were routinely measured in all cases, and theclinical indexes of the two groups of patients were compared to understand the clinical difference between the two diseases.Results The sex distribution(50.54% vs. 44.44%) and incidence of hypertension(24.73% vs. 38.27%) in NSPN-IMN group were not significantly different from those in NSPN-IgAN group (all P > 0.05).The rate of age > 50 years old in NSPN-IMN Group was higher than that in NSPN-IgAN Group (39.78% vs. 9.88%, P<0.01),and the incidence of renal dysfunction was lower than that in NSPN-IgAN group (4.30% vs. 22.22%,P < 0.01).Age[(47.31±13.85) vs. (35.28±12.68)], urine protein[(2.12±0.87)g/24 h vs. (1.18±0.84)g/24h], TC[(7.29± 2.16)mmol/L vs. (5.04±0.92)mmol/L], HDL[(1.82±0.63)mmol/L vs. (1.48±0.36)mmol/L] and LDL[(4.86±1.88)mmol/L vs. (3.31±0.68) mmol/L] in NSPN-IMN group were higher than those in NSPN-IgAN Group (all P < 0.01),while the serum albumin was lower than that in NSPN-IgAN group [(28.64±7.09)g/L vs. (40.36±6.58)g/L,P < 0.01].There was no significant difference in uric acid[(376.23±122.14) μmol/L vs. (364.70±127.41)μmol/L] and TG[(1.90±1.18)mmol/L vs. (1.61±1.18)mmol/L] between the two groups (P > 0.05).Conclusion |
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