| 高蓉,于玮慧,凌卫明,等.肺动脉高压三尖瓣反流压差与血脑钠肽前体及并发心力衰竭的关系[J].安徽医药,2021,25(2):349-352. |
| 肺动脉高压三尖瓣反流压差与血脑钠肽前体及并发心力衰竭的关系 |
| Relationship between pro-brain natriuretic peptide and tricuspid regurgitation pressure difference in patients with pulmonary hypertension and the complicated heart failure |
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| DOI：10.3969/j.issn.1009-6469.2021.02.033. |
| 中文关键词: 高血压，肺性 三尖瓣反流压差 脑钠肽前体 心力衰竭 |
| 英文关键词: Hypertension, pulmonary Tricuspid regurgitation pressure difference N-terminal pro-brain natriuretic peptide Heart failure |
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| 中文摘要: |
| 目的探讨肺动脉高压三尖瓣反流压差与血清脑钠肽前体(PRO-BNP)及并发心力衰竭的关系。方法选取 2016年 2月至 2018年 11月无锡市精神卫生中心收治的肺动脉高压病人 87例(疾病组)，另选取同期体检健康者 79例(健康组)，均采用多普勒超声心动图检测三尖瓣反流压差及采用电化学发光法测定血清 PRO-BNP水平，分析三尖瓣反流压差与血清 PRO-BNP水平的关系；另根据病人是否并发心力衰竭情况将疾病组分为心衰组与无心衰组，对比两组三尖瓣反流压差、血清 PRO-BNP水平，并采用 logistic回归分析法分析其与心衰的关系。结果疾病组三尖瓣反流压差及血清 PRO-BNP水平分别为( 52.17±6.58)mmHg、(619.72±113.47)ng/L，健康组分别为( 21.09±4.51)mmHg、(194.37±41.26)ng/L，疾病组均高于健康组，差异有统计学意义( P < 0.05)；经 Pearson相关性分析，疾病组三尖瓣反流压差与血清 PRO-BNP水平呈显著正相关( r=0.643，P < 0.05)； 87例肺动脉高压病人中共有 26例伴发心力衰竭，心力衰竭并发率为 29.89%(26/57)；心衰组三尖瓣反流压差及血清 PRO-BNP水平分别为( 60.15±6.23)mmHg、(698.79±115.08)ng/L，无心衰组分别为( 48.77±5.87)mmHg、(586.02±109.21)ng/L，心衰组均高于无心衰组，差异有统计学意义( P < 0.05)；经 logistic回归分析法分析，三尖瓣反流压差 > 50 mmHg及血清 PRO-BNP > 600 ng/L均是肺动脉高压病人伴发心力衰竭的危险因素( OR = 3.146、2.737，P < 0.05)。结论肺动脉高压病人三尖瓣反流压差明显增大，血清 PRO-BNP水平明显升高，此二者呈显著正相关，且三尖瓣反流压差可作为预测心衰的一项重要指标。 |
| 英文摘要: |
| Objective To investigate the relationship between serum pro-brain natriuretic peptide ( PRO-BNP) and tricuspid regurgitation pressure difference in patients with pulmonary hypertension and the complicated heart failure.Methods Totally 87 patientswith pulmonary hypertension (disease group) admitted to Wuxi Mental Health Center from February 2016 to November 2018 and 79healthy persons (healthy group) undergoing health check during the same period were selected. The tricuspid regurgitation pressure differences of them were detected by Doppler echocardiography and the serum pro-brain natriuretic peptide (PRO-BNP) levels of themwere measured by electrochemiluminescence, then the relationship between tricuspid regurgitation pressure difference and serum PROBNP level was analyzed. In addition, the patients of disease group were assigned further into heart failure group and non-heart failure group according to whether they were complicated with heart failure, and the tricuspid regurgitation pressure difference and serumPRO-BNP level were compared between the two groups, and the relationships between them and heart failure were analyzed by logisticregression analysis method.Results The tricuspid regurgitation pressure difference and serum PRO-BNP level of the disease groupwere (52.17±6.58) mmHg and (619.72±113.47) ng/L respectively, higher than those of the healthy group which were (21.09±4.51)mmHg and (194.37±41.26) ng/L respectively. The differences were significant (P < 0.05). Pearson correlation analysis showed thatthere was a significant positive correlation between the tricuspid regurgitation pressure difference and the serum PRO-BNP level in the disease group (r = 0.643,P < 0.05).There were 26 cases complicated with heart failure in 87 patients with pulmonary hypertension, thecomplication rate of heart failure being 29.89% (26/57). The tricuspid regurgitation pressure difference and serum PRO-BNP level of the heart failure group were (60.15±6.23) mmHg and (698.79±115.08) ng/L respectively, higher than those of the non-heart failure |
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