| 葛阳.柴枳平肝汤联合多潘立酮片治疗功能性消化不良肝胃不和证 54例及对胃肠激素、血清神经肽 S受体 -1水平的影响[J].安徽医药,2021,25(2):396-399. |
| 柴枳平肝汤联合多潘立酮片治疗功能性消化不良肝胃不和证 54例及对胃肠激素、血清神经肽 S受体 -1水平的影响 |
| Effect of Chaizhi Pinggan decoction plus domperidone tablets on gastrointestinal hormone and NPSR1 levels in patients with FD liver-stomach disharmony syndrome: an analysis of 54 cases |
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| DOI：10.3969/j.issn.1009-6469.2021.02.045. |
| 中文关键词: 消化不良 胃排空 柴枳平肝汤 肝胃不和证 胃肠激素 疗效 |
| 英文关键词: Dyspepsia Gastric emptying Chaizhi Pinggan decoction Liver and stomach incompetence Gastrointestinal hor mone Curative effect |
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| 中文摘要: |
| 目的观察柴枳平肝汤治疗功能性消化不良( FD)肝胃不和证对病人胃肠激素、血清神经肽 S受体 -1(NPSR1)水平的影响。方法选取三亚市中医院 2016年 10月至 2019年 2月收治的 FD肝胃不和证病人 108例，采用随机数字表法分为对照组和观察组，各 54例，分别给予单纯多潘立酮片治疗和柴枳平肝汤联合多潘立酮片治疗，比较两组治疗 4周后的临床效果。结4周后，观察组总有效率高于对照组，差异有统计学意义(90.74%比 75.93，P < 0.05)。两组治疗前胃动素(MTL)胃蛋白酶原果Ⅱ(PGⅡ)、生长抑素(SS)NPSR1、P物质(SP)热休克蛋白( HSP)水平组间比较，差异无统计学意义( P > 0.05)。观察、组治疗 4周后MTL［(472.54±30.41)pg、/mL比( 429.85±28.74、)pg/mL］、 PGⅡ［( 17.54±2.74)μg/L比( 14.11±2.58)μg/L］、 NPSR1［( 205.11±40.17)pg/mL比( 191.02±39.56)pg/mL］、 SP［( 75.84±5.45)pg/mL比( 59.56±4.78)pg/mL］水平高于对照组， SS［( 3.69±0.71)mg/L比(4.71±0.89)mg/L］、 HSP［(48.23±6.42)ng/mL比( 68.12±7.12)ng/mL］水平低于对照组( P < 0.05)。两组治疗前胃排空率、小肠推进率组间比较，差异无统计学意义( P > 0.05)。观察组治疗 4周后胃排空率［( 70.12±5.22)%比( 56.85±4.69)%］、小肠推进率［( 79.84±6.85)%比( 72.14±6.23)%］高于对照组( P < 0.05)。结论柴枳平肝汤治疗 FD肝胃不和证可调节胃肠激素、 NPSR1、 SP、HSP的表达水平，改善胃肠动力，提高疗效。 |
| 英文摘要: |
| Objective To observe the effect of Chaizhi Pinggan decoction on the levels of gastrointestinal hormone, serum neuropeptide S receptor-1(NPSR1) in the treatment of functional dyspepsia (FD) liver-stomach disharmony syndrome.Methods From October 2016 to February 2019 a total of 108 patients with FD liver-stomach disharmony syndrome treated in Traditional Chinese MedicineHospital of Sanya City were assigned into control group and observation group using random number table method, with respective 54cases in each group. The two groups were treated with domperidone tablets and Chaizhi Pinggan decoction combined with domperidonetablets, respectively. The clinical effects of the two groups after 4 weeks of treatment were compared.Results After 4-week treatment, the total effective rate in the observation group was higher than that in the control group (90.74% vs. 75.93,P < 0.05).The levels of motilin (MTL),pepsinogen II (PGⅡ),somatostatin (SS),NPSR1,substance P (SP) and heat shock protein (HSP) showed no significant difference between the two groups before treatment (P > 0.05). After 4 weeks of treatment,the MTL[(472.54±30.41)pg/mL vs. (429.85±28.74) pg/mL], PGⅡ[(17.54±2.74)μg/L vs. (14.11±2.58)μg/L],NPSR1[(205.11±40.17)pg/mL vs. (191.02±39.56)pg/mL], SP[(75.84±5.45)pg/ mL vs. (59.56±4.78)pg/mL] levels in the observation group were higher than those in the control group, and the SS[(3.69±0.71)mg/L vs. (4.71±0.89)mg/L], HSP [(48.23±6.42)ng/mL vs. (68.12±7.12)ng/mL] levels were lower in the observation group than those in the control group (P < 0.05).Before treatment, there were no significant differences in gastric emptying rate and small intestinal propulsion rate between the two groups (P > 0.05).The gastric emptying rate [(70.12±5.22)% vs. (56.85±4.69)%] and small intestinal propulsion rate [(79.84±6.85)% vs. (72.14±6.23)%] in the observation group were higher than those in the control group (P < 0.05).Conclusion Chai? zhi Pinggan decoction can regulate the expressions of gastrointestinal hormone, NPSR1, SP, and HSP, improve gastrointestinal motilityand improve the curative effect of FD with liver-stomach disharmony syndrome. |
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