| 王莉,蔡强.右美托咪定对重症肺炎机械通气病儿肠屏障功能的影响[J].安徽医药,2021,25(2):403-407. |
| 右美托咪定对重症肺炎机械通气病儿肠屏障功能的影响 |
| Effect of dexmedetomidine on intestinal barrier function in children with severe pneumonia undergoing mechanical ventilation |
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| DOI：10.3969/j.issn.1009-6469.2021.02.047. |
| 中文关键词: 右美托咪定 肺炎 呼吸，人工 肠屏障 儿童，学龄前 |
| 英文关键词: Dexmedetomidine Pneumonia Respiration, artificial Intestinal barrier Child, preschool |
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| 中文摘要: |
| 目的探讨右美托咪定( Dex)对重症肺炎机械通气病儿肠屏障功能的影响。方法选取 2016年 1月至 2019年 4月在宜宾市第二人民医院儿科重症监护室( PICU)收治的行机械通气治疗的重症肺炎病儿 92例为研究对象。采用随机数字表法将其分为观察组和对照组，各 46例。对照组予以咪达唑仑镇静，观察组予以 Dex镇静。两组治疗时间为 48 h。比较两组比用药(T0)、用药后 4h(T1)、 8h(T1)、24 h(T3)、 48 h(T4)心率(HR)和平均动脉压(MAP)；比较两组 T0T3、T4炎性因子指标［肿瘤坏死因前子-α(TNF-α)、白细胞介素 -6(IL-6)］和肠道通透性的指标［二胺氧化酶( DAO)D-乳酸(D-LAC)、］；比较两组治疗过程中药物不良反应。结果在 T1T2T3T4时观察组 HR［分别为( 112.43±6.12)次 /分，(112.27、±8.02)次 /分，(110.33±9.89)次 /分，(110.80± |
| 英文摘要: |
| Objective To explore the effect of dexmedetomidine on intestinal barrier function in children with severe pneumonia undergoing mechanical ventilation.Methods A total of 92 children with severe pneumonia treated with mechanical ventilation in the pediatric intensive care unit (PICU) of The Second People's Hospital of Yibin from January 2016 to April 2019 were selected as the studysubjects. The patients were assigned into observation group and control group by random number table method, with 46 cases in eachgroup.The control group was sedated with midazolam while the observation group was sedated with dexmedetomidine.The treatmenttime of the two groups was 48 hours. The heart rate (HR) and mean arterial pressure (MAP) of the two groups were compared beforemedication (T0),4 hours (T1),8 hours (T2),24 hours (T3),48 hours (T4) after administration.The inflammatory factors [tumor necrosis factorα (TNF-α), interleukin-6 (IL-6)] and indicators of intestinal permeability [diamine oxidase (DAO),D-lactic acid (D-LAC)] were compared between the two groups at T0, T3 and T4. The adverse drug reactions after treatment were compared between the two groups.Re? sults The HRs of observation group at T1,T2,T3 and T4 were (112.43±6.12) times/min, (112.27±8.02) times/min, (110.33±9.89) times/min,(110.80±9.47) times/min , respectively, which were significantly lower than those in the control group (P < 0.05).At T3 and T4 the levels of serum TNF-α of the observation group were (26.53±3.30) pg/mL,(19.21±2.39)pg/mL respectively and the levels of serum IL-6 of the observation group were (16.42±1.92)pg/mL,(12.09±1.59)pg/mL respectively, which were significantly lower than those in the con |
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