| 王晓兵,张湛,张琳琳.持续冲洗引流对食管癌术后吻合口瘘疗效和炎症的影响[J].安徽医药,2021,25(5):1016-1019. |
| 持续冲洗引流对食管癌术后吻合口瘘疗效和炎症的影响 |
| Effect of continuous drainage of thoracic cavity on the efficacy and inflammation of patients with anastomotic leakage after esophageal cancer operation |
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| DOI：10.3969/j.issn.1009-6469.2021.05.043 |
| 中文关键词: 吻合口瘘 食管肿瘤 持续冲洗引流 炎症 临床疗效 |
| 英文关键词: Anastomotic leak Esophageal neoplasms Continuous drainage of thoracic cavity Inflammation clinical efficacy |
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| 中文摘要: |
| 目的探讨持续冲洗引流对食管癌术后吻合口瘘病人疗效和炎症的影响。方法收集 2014年 8月至 2019年 8月安徽省肿瘤医院收治的食管癌术后吻合口瘘病人 80例，根据完全随机数字表原则将其分为观察组和对照组，每组 40例。对照组给予持续负压引流；观察组在对照组的基础上给予持续冲洗引流。客观评价持续冲洗引流对食管癌术后吻合口瘘病人的炎症指标降钙素原、 C反应蛋白( CRP)，白细胞介素 6(IL-6)和肿瘤坏死因子 α(TNF-α)，吻合口瘘愈合的时间，恢复进食的时间，住院时间，并发症的发生率，死亡率以及生活质量。结果经过治疗后，观察组 CRP［(85.81±9.98)mg/mL比( 98.34±11.02)mg/mL］、 IL-6［(259.28±31.69)pg/mL比( 302.49±29.32)pg/mL］、 TNF-α［(215.67±22.82)pg/mL比( 281.27±26.43)pg/mL］低于对照组(均 P< 0.01)观察组吻合口瘘愈合时间［( 17.37±1.78)d比( 32.09±2.24)d］恢复进食时间［( 11.09±1.12)d比( 15.51±1.35)d］和住院时间［( 2831±2.18)d比( 42.28±3.21)d］少于对照组(均 P<0.01)并发症发生率( 25.00%比 37.50%)和死亡率( 0.00%比，观察组，10.00%)低于对照组(均 P<0.05)，观察组术后 14 d生活质量于对照组［( 37.21±3.39)分比( 28.42±2.23)分， P<0.01］。结论 |
| 英文摘要: |
| Objective To investigate the effect of continuous drainage of thoracic cavity on the efficacy and inflammation of patientswith anastomotic leakage after esophageal cancer operation.Methods From August 2014 to August 2019, 80 patients with postoperative anastomotic leakage of esophageal cancer admitted to Anhui Cancer Hospital were enrolled. According to the principle of completerandom number table, they were divided into observation group and control group, with 40 cases in each group. Patients in the control group received continuous negative pressure drainage, while the observation group was given a continuous flushing drainage of the thoracic cavity on the basis of the control group. We objectively evaluated the inflammatory index (Procalcitonin, CRP, IL-6 and TNF-α),the time of anastomotic hernia healing, the time of recovery, the length of hospital stay, the complications, incidence, mortality and quality of life in patients with anastomotic leakage after esophageal cancer surgery.Results After treatment, the level of CRP [ (85.81± 9.98) mg/mL vs. (98.34±11.02) mg/mL], IL-6 [(259.28±31.69) pg/mL vs. (302.49±29.32) pg/mL], TNF-α [(215.67±22.82) pg/mL vs. (281.27±26.43) pg/mL] in the observation group was significantly lower than that in the control group (P<0.01). The time of anastomotic hernia healing [(17.37±1.78) d vs. (32.09±2.24) d] in the observation group was significantly shorter than that in the control group (P< 0.01), the incidence of complications (25.00% vs. 37.50%) and mortality (0.00% vs. 10.00%) in the observation group were significantlylower than those in the control group (P<0.05). The quality of life of the observation group was significantly higher than that of the control group [(37.21±3.39) vs. (28.42±2.23), P<0.01].Conclusion Continuous drainage of the thoracic cavity has a significant effect onthe improvement of postoperative anastomotic leakage in patients with esophageal cancer. It is worthy of clinical promotion. |
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