| 程晓晗,张杰.视黄醇结合蛋白 4和 C反应蛋白血清水平与绝经后乳腺癌发生转移的相关性[J].安徽医药,2021,25(5):1020-1024. |
| 视黄醇结合蛋白 4和 C反应蛋白血清水平与绝经后乳腺癌发生转移的相关性 |
| Retrospective analysis of the serum levels of RBP4 and CRP and the risk of breast cancer metastasis after menopause |
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| DOI：10.3969/j.issn.1009-6469.2021.05.044 |
| 中文关键词: 乳腺肿瘤 绝经后期 视黄醇结合蛋白 4 C反应蛋白 转移 细胞脂肪因子 |
| 英文关键词: Breast neoplasms Postmenopause Retinol binding protein 4 C-reactive protein Metastasis Adipokine |
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| 中文摘要: |
| 目的回顾性分析视黄醇结合蛋白 4(RBP4)和 C反应蛋白( CRP)血清水平与绝经后乳腺癌发生转移的相关性。方法收集蚌埠医学院第二附属医院 2016年 11月至 2020年 6月资料完整的绝经后乳腺癌 156例，其中 74例无转移为对照组， 82例已经转移为观察组。抽取血液样本，采用酶联免疫吸附法( ELISA)检测 RBP4及 CRP浓度。结果 logistic回归分析提示激素受体阴性、 Her-2阴性、 Ki67≥14%、高 RBP4、高 CRP是绝经后乳腺癌发生转移的危险因素( P<0.05)。观察组病人血清 RBP4和 CRP水平高于对照组［(38.68±6.39)μg/mL比( 35.09±4.95)μg/mL；(6.42±3.60)mg/L比( 4.67±2.72)mg/L］(P<0.05)。发生内脏转移病人血清 RBP4及 CRP水平高于发生骨转移病人。 ROC曲线下面积分析显示， RBP4联合 CRP检测可提高诊断的特异性和敏感性。结论血清 RBP4和 CRP与绝经后乳腺癌发生转移有明显相关性。 RBP4与 CRP对于诊断乳腺癌发生转移具有预测与评估价值。 |
| 英文摘要: |
| Objective To retrospectively analyze the correlation between serum levels of retinol binding protein 4 (RBP4) and C-reactive protein (CRP) and metastasis of postmenopausal breast cancer.Methods The clinical data of 156 women with postmenopausalbreast cancer who had complete data from November 2016 to June 2020 in the Second Affiliated Hospital of Bengbu Medical Collegewere collected. Among them, 74 cases were non-metastatic as control group, and 82 cases were metastatic as experimental group. Bloodsamples were taken and the concentration of RBP4 and CRP was detected by enzyme-linked immunosorbent assay (ELISA).Results logistic regression analysis showed that hormone receptor negative, HER-2 negative, Ki67 ≥ 14%, high RBP4 and high CRP were risk factors for postmenopausal breast cancer metastasis (P < 0.05). The levels of RBP4 and CRP in the experimental group were higher than those in the control group[(38.68±6.39)μg/mL vs. (35.09±4.95)μg/mL;(6.42±3.60)mg/L vs. (4.67±2.72)mg/L] (P < 0.05). The levelsof RBP4 and CRP in patients with visceral metastasis were higher than those in patients with bone metastasis. The area under the ROCcurve was analyzed, RBP4 combined with CRP detection can improve the specificity and sensitivity of diagnosis.Conclusion Serum RBP4 and CRP are significantly correlated with metastasis of postmenopausal breast cancer. RBP4 and CRP are of high value for thediagnosis of breast cancer metastasis. |
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