| 姚慧,吴发国,范家伟,等.血清骨钙素水平与老年 2型糖尿病病人慢性炎症指标的相关性[J].安徽医药,2021,25(8):1540-1543. |
| 血清骨钙素水平与老年 2型糖尿病病人慢性炎症指标的相关性 |
| Correlation between serum osteocalcin level and chronic inflammation in elderly patients with type 2 diabetes mellitus |
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| DOI：10.3969/j.issn.1009-6469.2021.08.015 |
| 中文关键词: 糖尿病， 2型 骨钙素 铁蛋白 慢性炎症 |
| 英文关键词: Diabetes mellitus, type 2 Osteocalcin Serum ferritin Chronic inflammation |
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| 中文摘要: |
| 目的探讨在老年 2型糖尿病( T2DM)病人中，血清骨钙素(OC)水平与慢性炎症指标的相关性。方法选取 2018年 6月至 2020年 3月在华东师范大学附属芜湖医院老年医学科住院的 192例病人作为研究对象，分为 T2DM组 92例，非 T2DM组 100例，比较两组受试者血清 OC水平、一般生化指标以及慢性炎症指标的关系，并分析在 T2DM组中，血清 OC水平与慢性炎症指标的关系。结果老年 T2DM病人的血清 OC水平较非 T2DM组显著下降［( 10.46±4.02)ng/mL比( 15.76±5.81)ng/mL，P<0.01］，而空腹血糖( FPG)、糖化血红蛋白( HbA1c)、餐后 2h血糖( 2hPG)、血清铁蛋白( SF)、超敏 C反应蛋白( Hs-CRP)、单核细胞计数( MONO)较非 T2DM组显著升高［( 10.05±3.48)mmol/L比( 5.18±0.70)mmol/L(8.18±1.47)%比( 5.51±0.31)%、(7.24±0.57) |
| 英文摘要: |
| Objective To investigate the relationship between serum osteocalcin(OC) level and chronic inflammation in elderly patients with type 2 diabetes mellitus(T2DM).Methods A total of 192 patients in our hospital from June 2018 to March 2020 were enrolled,including 92 patients with T2DM and 100 patients with non-T2DM.The serum OC level and general biochemical indicators aswell as chronic inflammation were compared between the two groups.In T2DM groups ,the relationship between serum OC level andchronic inflammation were also analyzed.Results Serum OC level in elderly T2DM patients was lower than that in the non-T2DM group[(10.46±4.02) ng/mL vs. (15.76±5.81)ng/mL,P<0.01],while the FPG,HBA1C,serum ferritin(SF),Hs-CRP and monocyte count was higher than that in the non-T2DM group[(10.05±3.48)mmol/l vs. (5.18±0.70)mmol/l,(8.18±1.47)% vs. (5.51±0.31)%,(7.24±0.57)mmol/ L vs.(5.46±0.29)mmol/L，(224.09±190.01)ng/mL vs. (146.06±133.01)ng/mL,(2.71±0.97)mmol/l vs. (2.10±0.76)mmol/l,(0.42±0.16) × 109/L vs. (0.37±0.12) ×109/L,P<0.01].In elderly patients with T2DM,There was a negatively correlation between serum OC level and SF、 Hs-CRP and eosinophil count.In addition,serum OC level was independently correlated with SF and Hs-CRP(P<0.05).Conclusion Serum OC level in elderly T2DM patients may be associated with chronic inflammation parameters. |
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