| 赵德喜,邵仲萍,候位,等.多巴丝肼联合综合康复训练对老年帕金森病病人认知及运动功能的影响[J].安徽医药,2021,25(9):1743-1749. |
| 多巴丝肼联合综合康复训练对老年帕金森病病人认知及运动功能的影响 |
| Effect of benserazide-levodopa combined with comprehensive rehabilitation training on cognitive and motor function in elderly patients with Parkinson's disease |
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| DOI：10.3969/j.issn.1009-6469.2021.09.011 |
| 中文关键词: 帕金森病 多巴丝肼 综合康复训练 老年人 认知功能 运动功能 |
| 英文关键词: Parkinson disease Benserazide-levodopa Comprehensive rehabilitation training Elderly Cognitive function Motor function |
| 基金项目:江苏大学医学临床科技发展基金项目( JLY20160125) |
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| 摘要点击次数: 1184 |
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| 中文摘要: |
| 目的探讨多巴丝肼联合综合康复训练对老年帕金森病病人认知及运动功能的影响。方法将 2014年 1月至 2017年 1月濉溪县医院 86例老年帕金森病病人以随机数字表法分为两组，对照组给予多巴丝肼单药治疗，观察组在多巴丝肼治疗基础上联合综合康复训练，疗程均为 3个月。对比两组多巴丝肼用药剂量，治疗前后认知功能、运动功能变化；评估联合治疗的临床疗效及安全性。结果两组多巴丝肼用药剂量差异无统计学意义( P>0.05)；治疗后两组视空间 /执行功能、命名、注意力、语言、抽象能力、定向力维度的认知功能分布与本组治疗前对比均差异有统计学意义( P<0.05)且治疗后两组对比均差异有统计学意义( P<0.05)；治疗后对照组和观察组记忆正确率分别为 67.44%和 88.37%，均较治疗前提，高( P<0.05)，且观察组高于对照组( P=0.019)；治疗后两组面部表情、手部动作、言语、手指捏合、肌强直、静止性震颤、手运动、手部快速交替运动、坐位到起立、膝关节屈曲状态下腿的灵活性、姿势、姿势的稳定性、步态、身体动作缓慢 /减少维度分布与本组治疗前对比均差异有统计学意义( P<0.05)且治疗后两组对比均差异有统计学意义( P<0.05)；两组临床疗效分布对比差异有统计学意义( P<0.05)，且观察组总有效为 93.0，2%，高于对照组的 74.42%(P=0.019)；对照组不良反应发生率与观察组相近( P>0.05)。结论对老年帕金森病病人给予多巴丝肼联合综合康复训练可显著改善认知及运动功能，增强疗效，且安全。 |
| 英文摘要: |
| Objective To explore the effects of benserazide-levodopa combined with comprehensive rehabilitation training on cognitive and motor functions in elderly patients with Parkinson's disease.Methods A total of 86 elderly patients with Parkinson's diseasein Suixi County Hospital from January 2014 to January 2017 were randomly divided into two groups. The control group was treated withbenserazide-levodopa alone. The combined treatment group was given comprehensive rehabilitation training on the basis of benserazidelevodopa. The dosage of medoba, changes of cognitive function and motor function before and after treatment were compared. The clinical efficacy and safety of combined therapy were compared.Results There was no significant difference in the dosage of medoba between the two groups (P > 0.05). There were significant differences in the distribution of cognitive function of visual space/executivefunction, naming, attention, language, Abstraction ability and orientation dimension in the two groups between before and after treatment (P < 0.05), and the differences between the two groups after treatment were statistically significant (P < 0.05). The correct rates ofmemory in control group and combined treatment group after treatment were 67.44% and 88.37%, respectively, which increased compared with those before treatment (P < 0.05), and that in the combined treatment group after treatment was higher than that in the control group (P = 0.019). There were significant differences in the distribution of motor function of vfacial expression, hand movement,speech, finger kneading, muscle stiffness, static tremor, hand movement, hand rapid alternating movement, sitting to stand, leg flexibility, posture, postural stability, gait, body movement slow/reduced dimension in the two groups between before and after treatment (P < 0.05), and the differences between the two groups after treatment were statistically significant (P < 0.05). There was a significant difference in the distribution of clinical efficacy between the two groups (P < 0.05), and the total effective rate of the combined treatmentgroup was 93.02%, which was higher than that of 74.42% in the control group (P = 0.019). The incidence of adverse reactions in the |
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