| Objective To explore the effect of Ulinastatin in the clinical treatment of patients with multiple trauma complicated with sepsis.Methods We retrospectively analyzed the case data of 106 patients with multiple injuries and sepsis admitted to The NinthPeople's Hospital of Suzhou from April 2017 to April 2019. According to the different treatment methods, all patients were assigned into two groups, with 53 cases in each. The control group was only given conventional treatment such as anti-infection, and the observation group was treated with additional ulinastatin intravenous drip twice a day on the basis of the therapy in the control group. Bothgroups were continuously administered for 1 week. The inflammatory status, T cell subset changes, hemodynamic parameters and the total effective rate of clinical treatment were compared between the two groups.Results After treatment, the levels of serum inflammatory factors, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factorα (TNF-α), procalcitonin and interleukin-6 (IL-6), were decreased in both groups, and the levels in the observation group were lower than those in the control group [(20.85±3.06) mg/L vs. (38.16±4.27) mg/L,(21.94±3.18) mg/L vs. (33.05±4.16) mg/L,(0.71±0.32) g/L vs. (1.29±0.44) g/L,(215.63±28.49) ng/L vs. (279.14± 36.85) ng/L,P<0.05]. In comparison with pre-treatment, the levels of CD3+, CD4+, CD4+/CD8+ were increased, and the levels of CD8+ were decreased in both groups. The levels of CD3+ [(60.12±9.84) % vs. (47.08±7.35) %], CD4+ [(44.96±8.15) % vs. (44.96±8.15) %], CD4+/CD8+ [(1.59±0.83) vs. (1.17±0.69)] in the observation group were higher than those in the control group and the level of CD8+ [(27.04±5.39) % vs. (33.07±6.22) %] in the observation group was lower than that in the control group (P<0.05). After treatment, the heart index (CI), stroke volume index (SVI), global end-diastolic volume increases (GEDVI), mean arterial pressure (MAP), and centralvenous pressure (CVP) of all patients in both groups increased, and the heart rate (HR) decreased in comparison with pretreatment. Thelevels of CI, SVI, GEDVI, MAP and CVP in the observation group were higher than those in the control group, and HR in the observation group was lower than that in the control group (P<0.05). The total response rate in the observation group was 94.34% (50/53), lower than that in the control group, which was 90.57% (48/53); there was no statistically significant difference between the two groups (χ2= 0.541,P=0.462).Conclusion For patients with multiple trauma complicated with sepsis, Ulinastatin can effectively help reduce the inflammatory response of the body, and improve the T cell subsets and hemodynamic parameters, which achieves certain clinical effects. |
