| 吴慧,缪阳,陈迎平,等.缺血性脑卒中神经功能缺损与血小板内皮聚集受体 1和前列腺素内过氧化物合酶 1基因多态性的关联分析[J].安徽医药,2021,25(10):2004-2008. |
| 缺血性脑卒中神经功能缺损与血小板内皮聚集受体 1和前列腺素内过氧化物合酶 1基因多态性的关联分析 |
| Correlation between PEAR1, PTGS1 gene polymorphism and neurological impairment in patients with ischemic stroke |
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| DOI：10.3969/j.issn.1009-6469.2021.10.022 |
| 中文关键词: 卒中 脑梗死 脑缺血 前列腺素内过氧化物合酶类 血小板 美国国立卫生研究院卒中量表 阿司匹林抵抗 基因多态性 |
| 英文关键词: Stroke Brain infarction Brain ischemia Prostaglandin-endoperoxide synthases Blood platelets NIHSS score Aspirin resistance Gene polymorphism |
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| 中文摘要: |
| 目的探讨阿司匹林抵抗相关基因血小板内皮聚集受体 1(PEAR1)和前列腺素内过氧化物合酶 1(PTGS1)多态性与缺血性脑卒中神经功能缺损程度的相关性。方法收集 2018年 10月至 2019年 12月盐城市第一人民医院收治的缺血性脑卒中病人 147例，根据美国国立卫生研究院卒中量表( NIHSS)评分将其分为轻症组和中重症组，应用聚合酶链反应( PCR)-荧光法进行 PEAR1和 PTGS1基因多态性检测，利用多因素回归分析阿司匹林相关基因多态性与缺血性脑卒中神经功能缺损的关系。结果两组病人年龄［( 63.7±12.8)岁比( 68.6±10.7)岁］、吸烟［18.46%(12/65)比 35.37%(29/82)］、糖尿病患病率［24.62%(16/ 65)比 42.68%(35/82)］、空腹血糖［( 5.87±1.69)mmol/L比( 7.38±3.11)mmol/L］、 D-二聚体［0.31(0.19，0.61)mg/L比 0.55(0.26，1.12)mg/L］差异有统计学意义( P<0.05)；两组病人 PEAR1基因型分布差异有统计学意义( P<0.05)，而 PTGS1基因型分布差异无统计学意义( P>0.05)；通过 logistic回归分析发现，年龄( OR:1.047，95%CI:1.023~1.072；P<0.001)、吸烟( OR:2.876， 95%CI:1.548~5.343；P=0.001)、空腹血糖( OR:1.390，95%CI:1.193~1.621；P<0.001)、 PEAR1基因携带 A等位基因( OR: 1.786，95%CI:1.028~3.101；P=0.040)与缺血性脑卒中神经功能缺损严重程度相关( P<0.05)。结论缺血性脑卒中神经功能缺损严重程度与年龄、吸烟、空腹血糖、 PEAR1基因携带 A等位基因有一定的相关性。 |
| 英文摘要: |
| Objective To explore the relevance between aspirin-resistance-related gene polymorphisms of platelet endothelial aggregation receptor 1 (PEAR1) and prostaglandin-endoperoxide synthase 1 (PTGS1) and neurological impairment in patients with ischemic stroke.Methods The medical records of 147 patients with ischemic stroke admitted to The First People's Hospital of Yancheng fromOctober 2018 to December 2019 were collected. According to NIHSS score, the patients were assigned into mild group and medium tosevere group. The genotypes of PEAR1 and PTGS1 were detected by polymerase chain reaction (PCR) -fluorescence technique. Multivariate regression analysis was used to analyze the correlation between aspirin-resistance-related gene polymorphism and neurological impairment in patients with ischemic stroke.Results There were significant differences in age [(63.7±12.8) years vs. (68.6±10.7) years], smoking [18.46% (12/65) vs. 35.37% (29/82)], prevalence of diabetes mellitus [24.62 % (16/65) vs. 42.68 % (35/82)], fasting blood glucose [(5.87±1.69) mmol/L vs. (7.38±3.11) mmol/L] and D-dimer [0.31 (0.19, 0.61) mg/L vs. 0.55 (0.26, 1.12) mg/L] between the two groups (P<0.05). There was significant difference in PEAR1 genotype distribution between the two groups (P<0.05), while no significant difference in PTGS1 genotype distribution (P>0.05). Logistic regression analysis showed that age (OR:1.047, 95%CI: 1.0231.072; P<0.001), smoking (OR:2.876, 95%CI: 1.548-5.343; P=0.001), fasting blood glucose (OR:1.390, 95%CI: 1.193-1.621; P<0.001) and A allele of PEAR1 gene (OR:1.786, 95%CI: 1.028-3.101; P=0.040) were correlated with the severity of neurological impairment in patients with ischemic stroke (P<0.05).Conclusion The severity of neurological impairment in patients with ischemic stroke may beassociated with age, smoking, fasting blood glucose and A allele of PEAR1 gene. |
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