| 汪浩森,齐共健.儿童脓毒症相关性脑病发生的危险因素分析[J].安徽医药,2021,25(11):2237-2240. |
| 儿童脓毒症相关性脑病发生的危险因素分析 |
| Risk factors of sepsis associated encephalopathy in children |
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| DOI：10.3969/j.issn.1009-6469.2021.11.026 |
| 中文关键词: 脓毒症相关性脑病 高同型半胱氨酸血症 高尿酸血症 危险因素 儿童 |
| 英文关键词: Sepsis associated encephalopathy Hyperhomocysteinemia Hyperuricemia Risk factor Children |
| 基金项目:徐州市科技项目重点研发计划(社会发展)(KC17165) |
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| 中文摘要: |
| 目的分析脓毒症病儿发生脓毒症相关性脑病( SAE)的危险因素。方法选取 2018年 1月至 2020年 2月入住徐州市儿童医院的脓毒症病儿 158例，其中符合 SAE诊断标准病儿 57例，未发生 SAE病儿 101例，通过单因素分析和多因素回归等方法，研究脓毒症病儿发生 SAE的危险因素。结果 SAE组病儿死亡率( 29.8%)高于非 SAE组( 9.9%)差异有统计学意义( P<0.05)。凝血功能障碍、高同型半胱氨酸血症、高尿酸血症是儿童 SAE发生的独立危险因素，差异有学意义( P<0.05)。结统计，论凝血功能障碍、高同型半胱氨酸血症、高尿酸血症对脓毒症病儿是否发生 SAE有一定预测价值。 |
| 英文摘要: |
| Objective To analyze the risk factors of sepsis associated encephalopathy (SAE) in children with sepsis.Methods One hundred and fifty-eight children with sepsis admitted to Xuzhou Children's Hospital from January 2018 to February 2020 were selected. Among them, 57 children met the SAE diagnostic criteria and 101 children did not have SAE. The risk factors of SAE in childrenwith sepsis were studied by univariate analysis and multivariate regression.Results The mortality rate of SAE group (29.8%) was higher than that of non-SAE group (9.9%), and the difference was statistically significant (P<0.05). Coagulation dysfunction, hyperhomocysteinemia and hyperuricemia were independent risk factors of SAE in children, and the difference was statistically significant (P<0.05). Conclusion Coagulation dysfunction, hyperhomocysteinemia and hyperuricemia have certain predictive value for the occurrence ofSAE in children with sepsis. |
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